| Identification | Back Directory | [Name]
PROSTAGLANDIN BX | [CAS]
39306-29-1 | [Synonyms]
pgbx
PROSTAGLANDIN BX
prostaglandinbx,sodiumsalt
Prostaglandin Bx Exclusive | [Molecular Formula]
C20H32O4 | [MDL Number]
MFCD00071377 | [MOL File]
39306-29-1.mol | [Molecular Weight]
336.466 |
| Hazard Information | Back Directory | [Uses]
Prostaglandin Bx (PGBx) is an oligomer of PGB1 and 15-keto-PGB, which exhibits mitochondrial protective efficacy. Prostaglandin Bx promotes the neurological recovery in rabbits ischemic spinal cord injury model, and maintains the integrity of the gastric mucosa through inhibition of gastric acid secretion in rat gastric ulcer model[1][2]. | [Definition]
ChEBI: Prostaglandin B1 is a member of the class of prostaglandins B that is prosta-8(12),13-dien-1-oic acid carrying oxo and hydroxy substituents at positions 9 and 15 respectively (the 13E,15S-stereoisomer). It has a role as a human metabolite. It is a conjugate acid of a prostaglandin B1(1-). | [Enzyme inhibitor]
This eicosanoid (FWB1 (free-acid) = 336.47 g/mol; CAS 13345-51-2, for PGB1, and 39306-29-1, for Bx) is a metabolite of prostaglandin E1: prostaglandin Bx is an oligomer of prostaglandin B1. The X-ray crystal structure of prostaglandin B1 suggests this prostaglandin has an unusual L-shaped configuration, with the a and w side chains roughly perpendicular to one another. The 15-hydroxyl group, which is normally directed away from the centroid of the prostaglandin in the standard hairpin mod+el, is turned inward in prostaglandin B1. Target (s) : FoF1 ATPase, or H-transporting two-sector ATPase, inhibited by prostaglandin Bx; 15- hydroxyprostaglandin dehydrogenase; phospholipase A2, inhibited by prostaglandin Bx. | [References]
[1] Kumashiro R, et al., Prostaglandin Bx in the prevention of stress ulcers in rats. Int Surg. 1985 Jul-Sep;70(3):247-50. PMID:3835168
[2] Jacobs TP, et al., Prostaglandin derivative PGBx improves neurologic recovery after ischemic spinal injury. Pharm Res. 1987 Apr;4(2):130-2. DOI:10.1023/a:1016466902877 |
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