ChemicalBook--->CAS DataBase List--->39637-99-5

39637-99-5

39637-99-5 Structure

39637-99-5 Structure
IdentificationMore
[Name]

(S)-(+)-ALPHA-METHOXY-ALPHA-TRIFLUOROMETHYLPHENYLACETYL CHLORIDE
[CAS]

39637-99-5
[Synonyms]

(+)-ALPHA-METHOXY-ALPHA-(TRIFLUOROMETHYL)PHENYLACETYL CHLORIDE
(+)-MOSHER'S ACID CHLORIDE
MOSHER'S ACID CHLORIDE
(+)-MOSHER'S CHLORIDE
(+)-MTPA-CL
(S)-(+)-1-METHOXY-1-(TRIFLUOROMETHYL)PHENYL ACETYL CHLORIDE
(S)-(+)-ALPHA-METHOXY-ALPHA-(TRIFLUOROMETHYL)BENZENEACETYLCHLORIDE
(S)-(-)-ALPHA-METHOXY-ALPHA-TRIFLUOROMETHYLPHENYLACETYL CHLORIDE
(S)-(+)-ALPHA-METHOXY-ALPHA-TRIFLUOROMETHYLPHENYLACETYL CHLORIDE
(S)-(+)-A-METHOXY-A-(TRIFLUOROMETHYL)PHENYLACETYL CHLORIDE
(S)-(+)-MTPA-CL
(R)-(fi)-alpha-methoxy-alpha-trifluoromethylphenylacetylchloride
(R)-(−
)-α-Methoxy-α-(trifluoromethyl)phenylacetyl chloride
(R)-(-)-A-METHOXY-A-(TRIFLUOROMETHYL)-PH ENYLACETYL CHLORIDE, 98%(98% EE/GLC)
(R)-(-)-Mosher'sacidchloride
(R)-(+)-1-Methoxy-1-(trifluoromethyl)phenylacetylchloride(ee)
(-)--Methoxy--(trifluoromethyl)phenylacetylchloride
(r)-(-)-à-methoxy-à-(trifluoromethyl)phenylacetyl chloride
(R)-(-)-1-Methoxy-1-(trifluoromethyl)phenylacetyl chloride 99% (99%ee)
(r)-(-)-alpha-methoxy-alpha-trifluoromethylphenylacetyl chloride (R)-(fi)-alpha-methoxy-alpha-trifluoromethylphenylacetyl chloride (r)-(-)-a-methoxy-a-(trifluoromethyl) phenylacetyl chloride
[EINECS(EC#)]

621-758-4
[Molecular Formula]

C10H8ClF3O2
[MDL Number]

MFCD00067105
[Molecular Weight]

252.62
[MOL File]

39637-99-5.mol
Chemical PropertiesBack Directory
[Appearance]

clear colorless to light yellow liquid
[alpha ]

D25 -10.0± 0.1° (neat, l = 1)
[Boiling point ]

213-214 °C(lit.)
[density ]

1.35 g/mL at 25 °C(lit.)
[refractive index ]

n20/D 1.469(lit.)
[Fp ]

194 °F
[storage temp. ]

−20°C
[form ]

Liquid
[color ]

Clear colorless to light yellow
[Specific Gravity]

1.353
[optical activity]

[α]20/D 137±2°, c = 6.4% in carbon tetrachloride
[Water Solubility ]

Sparingly miscible with water.
[Sensitive ]

Moisture Sensitive
[Merck ]

14,6280
[BRN ]

3591565
[CAS DataBase Reference]

39637-99-5(CAS DataBase Reference)
Safety DataBack Directory
[Hazard Codes ]

C
[Risk Statements ]

R34:Causes burns.
[Safety Statements ]

S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S27:Take off immediately all contaminated clothing .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) .
[RIDADR ]

UN 3265 8/PG 2
[WGK Germany ]

3
[F ]

10-21
[Hazard Note ]

Corrosive/Freeze
[HazardClass ]

8
[PackingGroup ]

II
[HS Code ]

29189900
Hazard InformationBack Directory
[Chemical Properties]

clear colorless to light yellow liquid
[Uses]

(R)-(-)-α-Methoxy-α-(trifluoromethyl)phenylacetyl chloride is used as a chiral acylating reagent, which is used in the resolution of amino acid enantiomers like 2,5-dimethoxy-4-methylamphetamine. It is also suitable for the determination of the optical composition of compounds extracted from biological fluids.
[Purification Methods]

The most likely impurity is the free acid due to hydrolysis and should be checked by IR. If free from acid, then distil, taking care to keep moisture out of the apparatus. Otherwise add SOCl2 and reflux for 5hours and distil it. Note that shorter reflux times result in a higher boiling fraction (b 130-155o/1mm) which has been identified as the anhydride. [Dale et al. J Org Chem 34 2543 1969, for enantiomeric purity see Dale & Mosher J Am Chem Soc 97 512 1973.]
Well-known Reagent Company Product InformationBack Directory
[Acros Organics]

(R)-(-)-alpha-Methoxy-alpha-trifluoromethylphenylacetyl chloride, 99%(39637-99-5)
[Alfa Aesar]

(R)-(-)-alpha-Methoxy-alpha-(trifluoromethyl)phenylacetyl chloride, 98+%(39637-99-5)
[Sigma Aldrich]

39637-99-5(sigmaaldrich)
[TCI AMERICA]

(-)-alpha-Methoxy-alpha-(trifluoromethyl)phenylacetyl Chloride  [for Determination of the optical purity of Alcohols and Amines],>98.0%(GC)(39637-99-5)
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