| Identification | More | [Name]
2-AMINO-5-BROMOBENZOPHENONE | [CAS]
39859-36-4 | [Synonyms]
2-AMINO-5-BROMOBENZOPHENONE
(2-AMINO-5-BROMO-PHENYL)-PHENYL-METHANONE
2-BENZOYL-4-BROMOANILINE
5-BROMO-2-AMINOBENZOPHENONE
IFLAB-BB F1386-0357
Methanone, (2-amino-5-bromophenyl)phenyl-
2-Benzoyl-4-bromoaniline
5-Bromo-2-aminobenzophenone | [Molecular Formula]
C13H10BrNO | [MDL Number]
MFCD00059962 | [Molecular Weight]
276.13 | [MOL File]
39859-36-4.mol |
| Chemical Properties | Back Directory | [Melting point ]
109-113℃ | [Boiling point ]
424.6±35.0 °C(Predicted) | [density ]
1.484±0.06 g/cm3(Predicted) | [storage temp. ]
Keep in dark place,Inert atmosphere,Room temperature | [solubility ]
DMF: 30 mg/ml; DMSO: 30 mg/ml; Ethanol: 30 mg/ml | [form ]
Powder | [pka]
-0.01±0.10(Predicted) | [color ]
Yellow | [InChI]
InChI=1S/C13H10BrNO/c14-10-6-7-12(15)11(8-10)13(16)9-4-2-1-3-5-9/h1-8H,15H2 | [InChIKey]
LXJVUGANBDAASB-UHFFFAOYSA-N | [SMILES]
C(C1=CC(Br)=CC=C1N)(C1=CC=CC=C1)=O | [CAS DataBase Reference]
39859-36-4(CAS DataBase Reference) |
| Safety Data | Back Directory | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection . | [HS Code ]
2922.39.4500 | [HazardClass ]
6.1 |
| Hazard Information | Back Directory | [Chemical Properties]
Pale Yellow Solid | [Uses]
2-Amino-5-bromobenzophenone is a benzophenone (B204980) derivative that is widely used in the synthesis of pharmaceutical compounds.
| [Synthesis]
The general procedure for the synthesis of 2-benzoyl-4-bromoaniline from 2-aminobenzophenone is as follows: reference is made to the synthesis of Example A16 (2-amino-5-bromophenyl)-phenyl-methanone, which can be accessed from US 20040127536 A1 and is based on the work of D. Roche, K. Prasad, O. Repic, TJ Blacklock in Tetrahedron Lett. 41, 2083-2085 (2000). This was done as follows: 2-aminobenzophenone (30 g, 152 mmol) was suspended in acetic acid (300 mL). Potassium bromide (19.9 g, 167 mmol), sodium perborate tetrahydrate (28 g, 183 mmol) and ammonium molybdate tetrahydrate (1.5 g) were subsequently added and the mixture was stirred continuously for 3 h at 0 °C. The dense yellow precipitate formed during the reaction was washed with ice water (300 mL) and subsequently separated by filtration, washed again with ice water and dried. Finally, 40.3 g (96% yield) of yellow solid product was obtained. Mass spectrometry analysis showed: m/z = 276 (M). | [References]
[1] Tetrahedron, 2007, vol. 63, # 13, p. 2811 - 2823
[2] Patent: US2006/94754, 2006, A1. Location in patent: Page/Page column 11
[3] Organic Letters, 2010, vol. 12, # 12, p. 2841 - 2843
[4] Chemical Communications, 2010, vol. 46, # 29, p. 5244 - 5246
[5] European Journal of Organic Chemistry, 2017, vol. 2017, # 31, p. 4600 - 4608 |
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J & K SCIENTIFIC LTD.
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Energy Chemical
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Jia Xing Isenchem Co.,Ltd
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