| Identification | Back Directory | [Name]
Chlorido[N,N'-disalicylidene-1,2-phenylenediamine]iron(III) | [CAS]
39916-28-4 | [Synonyms]
Chlorido[N,N&rsquo
-disalicylidene-1,2-phenylenediamine]iron(III)
Chlorido[N,N'-disalicylidene-1,2-phenylenediamine]iron(III) | [Molecular Formula]
C20H14ClFeN2O2 | [MOL File]
39916-28-4.mol | [Molecular Weight]
405.64 |
| Chemical Properties | Back Directory | [storage temp. ]
Store at -20°C | [solubility ]
DMF: 20 mg/ml; DMSO: 14 mg/ml; Ethanol: 0.3 mg/ml; PBS (pH 7.2): Partially soluble | [form ]
A crystalline solid |
| Hazard Information | Back Directory | [Description]
Chlorido[N,N'-disalicylidene-1,2-phenylenediamine]iron(III) is an inducer of ferroptosis.1 It induces ferroptosis, but not apoptosis or necroptosis, in NB1 cancer cells when used at a concentration of 3 μM.1 Chlorido[N,N'-disalicylidene-1,2-phenylenediamine]iron(III) inhibits proliferation of BJAB, NALM-6, Jurkat, MelHO, and MCF-7 cancer cells (IC50s = 0.07, 2.5, 1.5, 3, and 5 μM, respectively), as well as NALM-6 cells resistant to daunorubicin and vincristine when used at concentrations ranging from 0.04 to 0.125 μM.2 | [References]
1. Sagasser, J., Ma, B., Baecker, D., et al. A new approach in cancer treatment: Discovery of chlorido[N,N’-disalicylidene-1,2-phenylenediamine]iron(III) complexes as ferroptosis inducers J. Med. Chem. 62(17),8053-8061(2019).
2. Lee, S.-Y., Hille, A., Kitanovic, I., et al. [FeIII(salophene)Cl], a potent iron salophene complex overcomes multiple drug resistance in lymphoma and leukemia cells Leuk. Res. 35(3),387-393(2011). |
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