| Identification | More | [Name]
2,5-DIBROMO-6-METHYLPYRIDINE | [CAS]
39919-65-8 | [Synonyms]
2,5-DIBROMO-6-METHYLPYRIDINE
2,5-DIBROMO-6-PICOLINE
2,5-Dibromo-6-methylpyridine 98%
2,5-Dibromo-6-methylpyridine98%
3,6-Dibromo-2-picoline | [Molecular Formula]
C6H5Br2N | [MDL Number]
MFCD06254589 | [Molecular Weight]
250.92 | [MOL File]
39919-65-8.mol |
| Chemical Properties | Back Directory | [Appearance]
white to light yellow solid | [Melting point ]
0°C | [Boiling point ]
0°C | [density ]
1.911±0.06 g/cm3(Predicted) | [Fp ]
0°C | [storage temp. ]
Inert atmosphere,2-8°C | [solubility ]
soluble in Methanol | [form ]
powder to crystal | [pka]
-0.84±0.10(Predicted) | [color ]
White to Orange to Green | [InChI]
InChI=1S/C6H5Br2N/c1-4-5(7)2-3-6(8)9-4/h2-3H,1H3 | [InChIKey]
UCHKRHGVKYVGTC-UHFFFAOYSA-N | [SMILES]
C1(C)=NC(Br)=CC=C1Br | [CAS DataBase Reference]
39919-65-8(CAS DataBase Reference) |
| Safety Data | Back Directory | [Symbol(GHS) ]
 
GHS05,GHS06 | [Signal word ]
Danger | [Hazard statements ]
H301-H318 | [Precautionary statements ]
P280-P301+P310+P330-P305+P351+P338+P310 | [Hazard Codes ]
Xi,Xn | [Risk Statements ]
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed .
R36/37/38:Irritating to eyes, respiratory system and skin .
R41:Risk of serious damage to eyes.
R22:Harmful if swallowed. | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection . | [RIDADR ]
UN 2811 6.1/PG 3 | [WGK Germany ]
3 | [Hazard Note ]
Harmful | [REACH Registrations]
Active | [HazardClass ]
IRRITANT | [PackingGroup ]
III | [HS Code ]
29333990 | [Storage Class]
6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects | [Hazard Classifications]
Acute Tox. 3 Oral
Eye Dam. 1 |
| Hazard Information | Back Directory | [Chemical Properties]
white to light yellow solid | [Uses]
2,5-Dibromo-6-methylpyridine is a biochemical reagent that can be used as a biological material or organic compound for life science related research. | [Synthesis]
5-Bromo-2-amino-6-methylpyridine hydrobromide (29.4 kg, purity 76.5 wt%, 84 mol, 1.00 eq.) was dissolved in 48% hydrobromic acid (162.0 kg, 961 mol, 11.44 eq.) at a temperature below 35 °C. The resulting solution was cooled to 2 °C and bromine (43.0 kg, 269 mol, 3.20 eq.) was slowly added over 40 min. Subsequently, a 40 wt% aqueous sodium nitrite solution (28.9 kg, 419 mol, 4.99 eq.) was added dropwise over 50 min at a temperature range of -1 to 5 °C. The reaction mixture was kept at this temperature for 1 h. The pH was then adjusted to 13.1 with 50% aqueous sodium hydroxide solution (120.0 kg). the reaction solution was slowly warmed to 20 °C over 1 h and toluene (78.0 kg) was added. The mixture was stirred for 30 minutes and left to stand overnight. The clarified organic phase was obtained by filtration and washed twice with saturated aqueous sodium chloride solution (51.1 kg). A final 96.0 kg solution of 2,5-dibromo-6-methylpyridine (concentration 17.3 wt%) was obtained in 79% yield. | [References]
[1] Patent: WO2005/51954, 2005, A2. Location in patent: Page/Page column 38; 39 |
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