| Identification | More | [Name]
1-(ETHOXYCARBONYLMETHYL)PIPERAZINE | [CAS]
40004-08-8 | [Synonyms]
1-(ETHOXYCARBONYLMETHYL)PIPERAZINE
2-(PIPERAZIN-1-YL)-ACETIC ACID ETHYL ESTER
AKOS BBS-00006885
AKOS BC-0535
ETHYL 1-PIPERAZINEACETATE
ETHYL 2-(PIPERAZIN-1-YL)ACETATE
ETHYL PIPERAZIN-1-YLACETATE
ETHYL PIPERAZINOACETATE
N-(CARBOETHOXYMETHYL)-PIPERAZINE
N-(Carboethoxymethyl)piperazine~Ethyl (1-piperazino)acetate~(1-Piperazino)acetic acid ethyl ester
ethyl piperazine-1-acetate
ethyl (1-piperazino)acetate
1-Piperazineaceticacid,ethylester(7CI,9CI)
2-(PIPERAZIN-1-YL)-ACETIC ACID ETHYL ESTER >97%
1-(Ethoxycarbonylmethyl)piperazine, N-(Carboethoxymethyl)-piperazine, Ethyl 1-piperazineacetate
1-Piperazineacetic acid ethyl ester | [EINECS(EC#)]
254-745-3 | [Molecular Formula]
C8H16N2O2 | [MDL Number]
MFCD00040739 | [Molecular Weight]
172.22 | [MOL File]
40004-08-8.mol |
| Chemical Properties | Back Directory | [Boiling point ]
127°C 13mm | [density ]
1.048 g/mL at 20 °C(lit.)
| [refractive index ]
n20/D 1.472
| [Fp ]
127°C/13mm | [storage temp. ]
-20°C | [solubility ]
Chloroform, Methanol | [form ]
Oil | [pka]
8.96±0.10(Predicted) | [color ]
Clear | [Water Solubility ]
Soluble in water, chloroform, and methanol. | [Sensitive ]
Air Sensitive | [BRN ]
743260 | [Major Application]
peptide synthesis | [InChI]
1S/C8H16N2O2/c1-2-12-8(11)7-10-5-3-9-4-6-10/h9H,2-7H2,1H3 | [InChIKey]
MTFCXMJOGMHYAE-UHFFFAOYSA-N | [SMILES]
CCOC(=O)CN1CCNCC1 | [CAS DataBase Reference]
40004-08-8(CAS DataBase Reference) |
| Safety Data | Back Directory | [Symbol(GHS) ]
GHS07 | [Signal word ]
Warning | [Hazard statements ]
H315-H319-H335 | [Precautionary statements ]
P261-P264-P271-P280-P302+P352-P305+P351+P338 | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing . | [WGK Germany ]
3
| [Hazard Note ]
Irritant | [HazardClass ]
8 | [HS Code ]
2933599590 | [Storage Class]
10 - Combustible liquids | [Hazard Classifications]
Eye Irrit. 2
Skin Irrit. 2
STOT SE 3 |
| Hazard Information | Back Directory | [Chemical Properties]
1-(ETHOXYCARBONYLMETHYL)PIPERAZINE is Clear Thick Oil
| [Uses]
1-(ETHOXYCARBONYLMETHYL)PIPERAZINE is used in the preparation of aralkylpiperazine- and aryl-substituted hydrazines, particularly benzylpiperazineacetyl hydrazones of hydroxyaryl aldehydes, as selecti ve inducers of apoptosis and activators of procaspases for use as anticancer agents.
| [Uses]
N-(Ethoxycarbonylmethyl)piperazine is used in the preparation of aralkylpiperazine- and aryl-substituted hydrazines, particularly benzylpiperazineacetyl hydrazones of hydroxyaryl aldehydes, as selective inducers of apoptosis and activators of procaspases for use as anticancer agents. | [Definition]
ChEBI: Ethyl piperazinoacetate is an alpha-amino acid ester. | [reaction suitability]
reaction type: solution phase peptide synthesis | [Synthesis]
Step A: tert-butyl 4-ethoxycarbonylmethyl-piperazine-1-carboxylate Tert-butyl piperazine-1-carboxylate (2.62 g, 14 mmol), cesium carbonate (5 g, 15 mmol) and bromoacetic acid
ethyl ester (1.56 ml, 14 mmol) were stirred at room temperature for 1 |
|
| Company Name: |
J & K SCIENTIFIC LTD.
|
| Telephone: |
18210857532 18210857532 |
| Website: |
https://www.jkchemical.com |
| Company Name: |
Alfa Aesar
|
| Telephone: |
400-6106006 |
| Website: |
http://chemicals.thermofisher.cn |
| Company Name: |
Energy Chemical
|
| Telephone: |
400-0056266 |
| Website: |
www.energy-chemical.com |
| Company Name: |
Cool Pharm, Ltd
|
| Telephone: |
021-60455363 18019463053 |
| Website: |
www.coolpharm.com |
| Company Name: |
Sigma-Aldrich
|
| Telephone: |
021-61415566 800-8193336 |
| Website: |
https://www.sigmaaldrich.cn |
|