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402939-18-8

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402939-18-8 Structure

402939-18-8 Structure
IdentificationBack Directory
[Name]

Soluble Epoxide Hydrolase Inhibitor, NCND - CAS 402939-18-8 - Calbiochem
[CAS]

402939-18-8
[Synonyms]

Soluble Epoxide Hydrolase Inhibitor, NCND - CAS 402939-18-8 - Calbiochem
[Molecular Formula]

C19H38N2O
[MOL File]

402939-18-8.mol
[Molecular Weight]

310.52
Chemical PropertiesBack Directory
[Boiling point ]

465.1±12.0 °C(Predicted)
[density ]

0.92±0.1 g/cm3(Predicted)
[storage temp. ]

Store at -20°C
[solubility ]

Ethanol: 16.67 mg/mL (53.68 mM)
[form ]

Solid
[pka]

14.29±0.20(Predicted)
[color ]

White to off-white
Hazard InformationBack Directory
[Uses]

1-Cyclohexyl-3-dodecyl urea (CDU; N-Cyclohexyl-N-dodecyl urea; NCND) is a highly selective soluble epoxide hydrolase (sEH) inhibitor. 1-Cyclohexyl-3-dodecyl urea (CDU; N-Cyclohexyl-N-dodecyl urea; NCND) increases epoxyeicosatrienoic acids (EETs) levels and lowers blood pressure in angiotensin II (Ang II) hypertension[1].
[Biological Activity]

Cell permeable: yes''Primary Target
Soluble epoxide hydrolase''Product competes with ATP.''Reversible: no''Target IC50: 9.8 nM for mouse recombinant sEH85.2 nM for human recombinant sEH
[in vivo]

1-Cyclohexyl-3-dodecyl urea (CDU; N-Cyclohexyl-N-dodecyl urea; NCND) (?intraperitoneal injection; 3mg/day; 4 days) lowers systolic blood pressure by 30 mm Hg in Ang II hypertensive animals, whereas the corn oil vehicle has no effect on blood pressure in normotensive or Ang II hypertensive animals[1].

Animal Model:Male Sprague-Dawley rats[1]
Dosage:3mg/day
Administration:Intraperitoneal injection; 4 days
Result:Had antihypertensive properties.
[storage]

Store at -20°C
[References]

[1] Imig JD,et al. Soluble epoxide hydrolase inhibition lowers arterial blood pressure in angiotensin II hypertension.Hypertension. 2002 Feb;39(2 Pt 2):690-4. DOI:10.1161/hy0202.103788
Spectrum DetailBack Directory
[Spectrum Detail]

Soluble Epoxide Hydrolase Inhibitor, NCND - CAS 402939-18-8 - Calbiochem(402939-18-8)1HNMR
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