| Identification | Back Directory | [Name]
6-Chloro-2a-[4-[4-(4-chlorophenyl)-3,6-dihydro-1(2H)-pyridinyl]butyl]-2a,3,4,5-tetrahydrobenz[cd]indol-2(1H)-one hydrochloride | [CAS]
402942-53-4 | [Synonyms]
DR 4485 hydrochloride
DR4485 hydrochloride,DR-4485 hydrochloride
6-Chloro-2a-[4-[4-(4-chlorophenyl)-3,6-dihydro-1(2H)-pyridinyl]butyl]-2a,3,4,5-tetrahydrobenz[cd]indol-2(1H)-one hydrochloride | [Molecular Formula]
C26H29Cl3N2O | [MDL Number]
MFCD28133386 | [MOL File]
402942-53-4.mol | [Molecular Weight]
491.88 |
| Hazard Information | Back Directory | [Uses]
DR4485 (hydrochloride) is an orally active and selective 5-HT7 antagonist (pKi=8.14)[1]. | [IC 50]
5-HT7 Receptor: 8.14 (pKi) | [storage]
Desiccate at RT | [References]
[1] Kikuchi C, et al. New tetrahydrobenzindoles as potent and selective 5-HT(7) antagonists with increased In vitro metabolic stability. Bioorg Med Chem Lett. 2003;13(1):61-64. DOI:10.1016/s0960-894x(02)00842-9
[2] Meyer N, et al. Autophagy activation, lipotoxicity and lysosomal membrane permeabilization synergize to promote pimozide- and loperamide-induced glioma cell death [published online ahead of print, 2021 Jan 19]. Autophagy. 2021;1-20. DOI:10.1080/15548627.2021.1874208 |
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