403-32-7

403-42-9

403-32-7

The general procedure for the synthesis of 4-fluorobenzoylformaldehyde from 4-fluoroacetophenone was as follows: selenium dioxide (6.70 g, 61.0 mmol) was added to a mixed solution of dioxane (100 mL) and water (3 mL) containing 4-fluoroacetophenone (8.43 g, 61.0 mmol). The resulting mixture was heated at 55 °C until selenium dioxide was completely dissolved. Subsequently, the reaction mixture was refluxed for 5 to 6 hours. After monitoring the completion of the reaction by thin layer chromatography (TLC), the mixture was filtered and the filtrate was concentrated under vacuum to obtain a viscous oily substance. Water (50 mL) was added to the oily substance and the resulting mixture was stirred for 12 hours. Afterwards, the solid formed was collected on a filter, washed with water (25 mL) and dried under vacuum to finally obtain 4-fluorophenylglyoxal (6.60 g, 85% yield).1H NMR (400 MHz, CDCl3) δ: 7.18 (m, 2H), 8.11 (d, 2H), no signal for aldehyde CHO was observed.