| Identification | Back Directory | [Name]
1,2,3,4-Tetrahydro-4-oxo-N-(phenylmethyl)-2-thioxo-3-[3-(trifluoromethyl)phenyl]-7-quinazolinecarboxamide | [CAS]
403718-45-6 | [Synonyms]
Qc1
Threonine Dehydrogenase Inhibitor, QC1
Threonine Dehydrogenase Inhibitor, QC1 - CAS 403718-45-6 - Calbiochem
N-Benzyl-4-oxo-2-thioxo-3-(3-(trifluoromethyl)phenyl)-1,2,3,4-tetrahydroquinazoline-7-carboxamide
1,2,3,4-Tetrahydro-4-oxo-N-(phenylmethyl)-2-thioxo-3-[3-(trifluoromethyl)phenyl]-7-quinazolinecarboxamide
7-Quinazolinecarboxamide, 1,2,3,4-tetrahydro-4-oxo-N-(phenylmethyl)-2-thioxo-3-[3-(trifluoromethyl)phenyl]- | [Molecular Formula]
C23H16F3N3O2S | [MDL Number]
MFCD02649259 | [MOL File]
403718-45-6.mol | [Molecular Weight]
455.45 |
| Chemical Properties | Back Directory | [density ]
1.48±0.1 g/cm3(Predicted) | [storage temp. ]
2-8°C | [solubility ]
DMSO: soluble5mg/mL (clear solution, warmed) | [form ]
White powder | [pka]
10.13±0.20(Predicted) | [color ]
white to beige | [InChI]
1S/C23H16F3N3O2S/c24-23(25,26)16-7-4-8-17(12-16)29-21(31)18-10-9-15(11-19(18)28-22(29)32)20(30)27-13-14-5-2-1-3-6-14/h1-12H,13H2,(H,27,30)(H,28,32) | [InChIKey]
IFNVTSPDMUUAFY-UHFFFAOYSA-N | [SMILES]
FC(F)(F)c1cccc(c1)N2C(=S)Nc3cc(ccc3C2=O)C(=O)NCc4ccccc4 |
| Hazard Information | Back Directory | [Uses]
Qc 1 is used in the preparation of bis(benzylcarbamoyl)methylthio dihydroquinazolinones. | [Biological Activity]
Qc1 is a reversible inhibitor of threonine dehydroxygenase (TDH). The IC50 value for inhibition of TDH by Qc1 is 500 nMwith no detectable inhibition of other dehydroxygenase enzymes at concentrations up to 10 mM. Qc1 induces arrest and autophagy of mouse ES cells with an EC50 of 3 mM. |
|
| Company Name: |
BOC Sciences
|
| Tel: |
|
| Website: |
https://www.bocsci.com |
| Company Name: |
Merck KGaA
|
| Tel: |
21-20338288 |
| Website: |
www.sigmaaldrich.cn |
|