| Identification | Back Directory | [Name]
ACHP | [CAS]
406208-42-2 | [Synonyms]
ACHP
2-Amino-6-[2-(cyclopropylmethoxy)-6-hydroxyphenyl]-4-(4-piperidinyl)nicotinonitrile
2-Amino-6-[2-(cyclopropylmethoxy)-6-hydroxyphenyl]-4-(4-piperidinyl)-3-pyridinecarbonitrile
3-Pyridinecarbonitrile, 2-amino-6-[2-(cyclopropylmethoxy)-6-hydroxyphenyl]-4-(4-piperidinyl)- | [Molecular Formula]
C21H24N4O2 | [MDL Number]
MFCD26792569 | [MOL File]
406208-42-2.mol | [Molecular Weight]
364.44 |
| Chemical Properties | Back Directory | [storage temp. ]
Store at -20°C | [solubility ]
<7.29mg/ml in DMSO | [form ]
solid | [color ]
Yellow | [InChI]
1S/C21H24N4O2/c22-11-16-15(14-6-8-24-9-7-14)10-17(25-21(16)23)20-18(26)2-1-3-19(20)27-12-13-4-5-13/h1-3,10,13-14,24,26H,4-9,12H2,(H2,23,25) | [InChIKey]
DYVFBWXIOCLHPP-UHFFFAOYSA-N | [SMILES]
N1CCC(CC1)c2c(c(nc(c2)c3c(cccc3O)OCC4CC4)N)C#N |
| Hazard Information | Back Directory | [Uses]
ACHP is an IkB kinase inhibitor, which has dose-dependently inhibited cell growth with inhibition of phosphorylation of IκBα/p65 and NF-κB DNA-binding, down-regulation of NF-κB target genes and induced apoptosis in human myeloma cell lines. | [Definition]
ChEBI: 2-amino-6-[2-(cyclopropylmethoxy)-6-oxo-1-cyclohexa-2,4-dienylidene]-4-(4-piperidinyl)-1H-pyridine-3-carbonitrile is a member of quinomethanes. | [Biological Activity]
achp is an iκb kinase inhibitor. nuclear factor-kb (nf-kb) involved in cell survival and proliferation of multiple myeloma has been well established. | [in vitro]
achp is selective for ikkα and ikkβ over ikk3, syk and mapkkk4 (ic50 > 20 μm), dna binding activity of nf-κb is inhibited. achp is an effective blockade nf-κb pathway in multiple myeloma cell lines, and induces cell growth arrest and apoptosis. it was observed that nf-kb is constitutively activated in all human myeloma cell lines, thus confirming the previous studies. in addition, it was found the phosphorylation of p65 subunit of nf-kb besides the phosphorylation of ikba and the activation of nf-kb dna binding and that various target genes of nf-kb including bcl-xl, xiap, c-iap1, cyclin d1, and il-6 are up-regulated. 2-amino-6-[2-(cyclopropylmethoxy)-6-hydroxyphenyl]-4-piperidin-4-yl nicotinenitrile (achp) is a novel ikb kinase inhibitor. treatment of myeloma cells with achp showed the cell growth was efficiently inhibited (ic50 values ranging from 18 to 35 mmol/l) concomitantly with inhibition of the phosphorylation of ikba/p65 and nf-kb dna-binding, down-regulation of the nf-kb target genes, and then induction of apoptosis. in addition, the treatment of achp potentiated the cytotoxic effects of vincristine and melphalan (l-phenylalanine mustard), conventional antimyeloma drugs. these findings suggest that by blocking the antiapoptotic nature of myeloma cells endowed by the constitutive activation of nf-kb, ikb kinase inhibitors such as achp can sensitize myeloma cells to the cytotoxic effects of chemotherapeutic agents. | [Enzyme inhibitor]
This novel IKK inhibitor (FW = 364.44 g/mol; CAS 406208-42-2; Soluble to 20 mM in DMSO), also named 2-amino-6-[2-(cyclopropylmethoxy)-6hydroxyphenyl]-4-(4-piperidinyl)-3-pyridinecarbonitrile, targets IκB kinases, with respective IC50 values of 8.5 and 250 nM for IKKβ and IKKα. ACHP’s selectivity is indicated by its > 20-μM IC50 values toward IKK3, Syk, and MAPKKK4. Inhibition of the TNFα-mediated gene expression could occur at low ACHP concentration (<1 μmol/L), with higher concentrations (>10 μmol/L) required to inhibit the constitutive phosphorylation of p65, expression of NF-κB-mediated genes (e.g., CYCLIN D1, BCL-xL, XIAP, c-IAP1, and IL-6), ultimately achieving myeloma cytostasis. Such findings indicate that ACHP’s growth inhibitory effects may be mediated through inhibition of both IKKα and IKKβ. By inhibiting NF-κB’s DNA binding activity, ACHP blocks the NF-κB pathway in multiple myeloma cell lines, inducing growth arrest and apoptosis. | [IC 50]
8.5 and 250 nm for ikkβ and ikkα, respectively | [storage]
Store at -20°C | [References]
[1] sanda t, iida s, ogura h, asamitsu k, murata t, bacon kb, ueda r, okamoto t. growth inhibition of multiple myeloma cells by a novel ikappab kinase inhibitor. clin cancer res. 2005 mar 1;11(5):1974-82. |
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BOC Sciences
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https://www.bocsci.com |
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