| Identification | Back Directory | [Name]
Isoviolanthin | [CAS]
40788-84-9 | [Synonyms]
Isoviolanthin
4H-1-Benzopyran-4-one, 6-(6-deoxy-α-L-mannopyranosyl)-8-β-D-glucopyranosyl-5,7-dihydroxy-2-(4-hydroxyphenyl)- | [Molecular Formula]
C27H30O14 | [MDL Number]
MFCD32197403 | [MOL File]
40788-84-9.mol | [Molecular Weight]
578.52 |
| Chemical Properties | Back Directory | [Boiling point ]
925.3±65.0 °C(Predicted) | [density ]
1.703±0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
5.70±0.40(Predicted) | [color ]
Light yellow to yellow | [InChIKey]
TWBWSPDILHVKEV-RSPRXDBDSA-N | [SMILES]
O1[C@@H]([C@H]([C@@H]([C@H]([C@@H]1c2c3[o]c(c[c](c3c(c(c2O)[C@@H]5O[C@H]([C@@H]([C@H]([C@H]5O)O)O)C)O)=O)c4ccc(cc4)O)O)O)O)CO |
| Hazard Information | Back Directory | [Uses]
Isoviolanthin, a flavonoid glycoside, could markedly inhibit TGF-β1-mediated migration and invasion by deactivating epithelial-mesenchymal transition (EMT) via the TGF-β/Smad and PI3K/Akt/mTOR pathways in HCC cells. Isoviolanthin exhibits no cytotoxic effects on normal liver LO2 cells[1]. | [References]
[1] Xing S, et al. Isoviolanthin Extracted from Dendrobium officinale Reverses TGF-β1-Mediated Epithelial?Mesenchymal Transition in Hepatocellular Carcinoma Cells via Deactivating the TGF-β/Smad and PI3K/Akt/mTOR Signaling Pathways. Int J Mol Sci. 2018 May 23;19(6). DOI:10.3390/ijms19061556 |
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