| Identification | More | [Name]
4,4'-DICHLOROBUTYROPHENONE | [CAS]
40877-09-6 | [Synonyms]
4,4'-DICHLOROBUTYROPHENONE
4-CHLORO-1-(4-CHLOROPHENYL)-1-BUTANONE
4-CHLORO-1-(4-CHLOROPHENYL)-1-OXOBUTANE
GAMMA,4-DICHLOROBUTYROPHENONE
GAMMA,P-DICHLOROBUTYROPHENONE
LABOTEST-BB LT00848184
4-Chlorophenyl 3-chloropropyl ketone
4-chloro-1-(4-chlorophenyl)butan-1-one
4',γ-Dichlorobutyrophenone | [EINECS(EC#)]
255-123-4 | [Molecular Formula]
C10H10Cl2O | [MDL Number]
MFCD00018993 | [Molecular Weight]
217.09 | [MOL File]
40877-09-6.mol |
| Safety Data | Back Directory | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S24/25:Avoid contact with skin and eyes . |
| Hazard Information | Back Directory | [Chemical Properties]
clear yellow to brown liquid after melting | [Synthesis]
To a dry reaction tube were sequentially added 0.2 mmol 1-(4-chlorophenyl)cyclobutanol, 0.02 mmol manganese dichloride (MnCl2), 0.6 mmol trimethylsilyl chloride (TMSCl), 0.4 mmol 2-iodobenzoic acid and 1 mL acetonitrile (MeCN). The reaction mixture was stirred at 50°C for 7 hours. After completion of the reaction, the solvent was removed by distillation under reduced pressure. The crude product was purified by column chromatography using a solvent mixture of petroleum ether and ethyl acetate as eluent (20:1 v/v). The final product was 4,4'-dichlorobutyrophenone in 88.2% yield and 98% purity. | [References]
[1] Organic Letters, 2016, vol. 18, # 4, p. 684 - 687
[2] Patent: CN106008181, 2016, A. Location in patent: Paragraph 0039-0041 |
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