| Identification | Back Directory | [Name]
Medioresil | [CAS]
40957-99-1 | [Synonyms]
Medioresil
Medioresinol
(+)-Medioresinol
Medioresil ISO 9001：2015 REACH
4-[(1S,3aR,4S,6aR)-4-(4-Hydroxy-3-methoxyphenyl)tetrahydro-1H,3H-furo[3,4-c]furan-1-yl]-2,6-dimethoxyphenol
Phenol,2,6-dimethoxy-4-[(1S,3aR,4S,6aR)- tetrahydro-4-(4-hydroxy-3-methoxyphenyl)- 1H,3H-furo[3,4-c]furan-1-yl]-
4-[(3S,3aR,6S,6aR)-3-(4-hydroxy-3-methoxyphenyl)-1,3,3a,4,6,6a-hexahydrofuro[3,4-c]furan-6-yl]-2,6-dimethoxyphenol | [Molecular Formula]
C21H24O7 | [MDL Number]
MFCD20275045 | [MOL File]
40957-99-1.mol | [Molecular Weight]
388.41 |
| Chemical Properties | Back Directory | [Melting point ]
170-172 °C(Solv: methanol (67-56-1)) | [Boiling point ]
575.7±50.0 °C(Predicted) | [density ]
1.284±0.06 g/cm3(Predicted) | [storage temp. ]
4°C, protect from light | [form ]
Solid | [pka]
9.84±0.35(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
(+)-Medioresinol is a furofuran type lignan with antifungal, antibacterial and lesishmanicidal activities. (+)-Medioresinol leads to intracellular ROS accumulation and mitochondria-mediated apoptotic cell death in Candida albicans. (+)-Medioresinol can reduce the cardiovascular disease risk[1][2]. | [Definition]
ChEBI: (-)-medioresinol is a lignan that is tetrahydro-1H,3H-furo[3,4-c]furan substituted by a 4-hydroxy-3,5-dimethoxyphenyl group at position 1 and a 4-hydroxy-3-methoxyphenyl group at position 4. It has been isolated from the stems of Sinocalamus affinis. It has a role as a plant metabolite. It is a lignan, a dimethoxybenzene, a furofuran and a polyphenol. | [References]
[1] Ji Hong Hwang, et al. (+)-Medioresinol leads to intracellular ROS accumulation and mitochondria-mediated apoptotic cell death in Candida albicans. Biochimie. 2012 Aug;94(8):1784-93. DOI:10.1016/j.biochi.2012.04.010
[2] Ji Hong Hwang, et al. Synergistic antibacterial and antibiofilm effect between (+)-medioresinol and antibiotics in vitro. Appl Biochem Biotechnol. 2013 Aug;170(8):1934-41. DOI:10.1007/s12010-013-0351-7 |
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BioBioPha Co., Ltd.
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0871-65217109 13211707573; |
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http://www.biobiopha.com |
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