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411208-45-2

411208-45-2 Structure

411208-45-2 Structure
IdentificationBack Directory
[Name]

MADAM DIHYDROCHLORIDE
[CAS]

411208-45-2
[Synonyms]

Benzenemethanamine, 2-[(2-amino-4-methylphenyl)thio]-N,N-dimethyl-
2-((2-((dimethylamino)methyl)phenyl)thio)-5-methylaniline dihydrochloride
[Molecular Formula]

C16H20N2S
[MDL Number]

MFCD07370142
[MOL File]

411208-45-2.mol
[Molecular Weight]

272.41
Chemical PropertiesBack Directory
[Boiling point ]

367.5±42.0 °C(Predicted)
[density ]

1.14±0.1 g/cm3(Predicted)
[storage temp. ]

2-8°C
[solubility ]

H2O: ~18 mg/mL
[pka]

8.47±0.28(Predicted)
[color ]

white
Safety DataBack Directory
[Hazard Codes ]

Xi
[Risk Statements ]

36/37/38
[Safety Statements ]

26-36
[WGK Germany ]

3
Hazard InformationBack Directory
[Uses]

MADAM exhibits high affinity and selectivity for 5-HTT with a Ki value of 1.6 nM. MADAM has the potential to serve as a PET radiotracer for visualizing the serotonin transporter[1].
[References]

[1] J. Tarkiainen, et al. Carbon-11 labelling of madam in two different positions: A highly selective pet radioligand for the serotonin transporter. Journal of Labelled Compounds and Radiopharmaceuticals. Volume44, IssueS1.
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