| Identification | Back Directory | [Name]
4-IODO-6-PHENYLPYRIMIDINE | [CAS]
41270-96-6 | [Synonyms]
4-IPP
MIF Antagonist III, 4-IPP
4-IODO-6-PHENYLPYRIMIDINE
Pyrimidine, 4-iodo-6-phenyl-
4-IPP (4-Iodo-6-phenylpyrimidine)
MIF Antagonist III, 4-IPP - CAS 41270-96-6 - Calbiochem | [Molecular Formula]
C10H7IN2 | [MDL Number]
MFCD00234609 | [MOL File]
41270-96-6.mol | [Molecular Weight]
282.08 |
| Chemical Properties | Back Directory | [Boiling point ]
380.2±30.0 °C(Predicted) | [density ]
1.728±0.06 g/cm3(Predicted) | [storage temp. ]
-20°C | [solubility ]
DMSO: soluble10mg/mL (clear solution, warmed) | [form ]
powder | [pka]
-0.54±0.17(Predicted) | [color ]
white to beige | [InChIKey]
ZTCJXHNJVLUUMR-UHFFFAOYSA-N |
| Hazard Information | Back Directory | [Uses]
4-IPP has been used as a macrophage migration inhibitory factor (MIF) in conditioned medium (CM) for in vitro migration assay. | [Definition]
ChEBI: 4-iodo-6-phenylpyrimidine is a member of the class of pyrimidines carrying iodo and phenyl substituents at positions 4 and 6 respectively. It has a role as a macrophage migration inhibitory factor inhibitor, an antineoplastic agent and an apoptosis inducer. It is a member of pyrimidines, a biaryl and an organoiodine compound. | [Biological Activity]
Inhibitor of macrophage migration inhibitor factor (MIF). Acts as a suicide substrate to inactivate MIF catalytic and biological functions; inhibits MIF-associated liver enzyme activity in vivo . Also inhibits migration and anchorage independence of human lung adenocarcinoma cell lines in vitro . | [Biochem/physiol Actions]
4-Iodo-6-phenylpyrimidine (4-IPP) has the potential to be a new anti-polyploid therapeutic agent that may be utilized in patients with thyroid cancer to target polyploid tumor cells. It suppresses osteoclastogenesis by blocking the IMF-κB pathway. 4-IPP can be employed as a therapeutic target for macrophage migration inhibitory factor (MIF) to treat pathologic osteolytic bone diseases and postmenopausal bone loss. It can prevent the development and motility of lung adenocarcinoma cells and can stimulate apoptosis and mitotic death of thyroid carcinomas. | [storage]
Store at -20°C |
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