| Identification | Back Directory | [Name]
3-(4-Chlorophenyl)-4-[[[(4-chlorophenyl)amino]carbonyl]hydroxyamino]-5,5-dimethyl-2-oxo-1-imidazolidineaceticacid2-[3-(5-nitro-2-furanyl)-2-propen-1-ylidene]hydrazide | [CAS]
412960-54-4 | [Synonyms]
Eeyarestatin I
Eeyarestatin 1
Eeyarestatin I - CAS 412960-54-4 - Calbiochem
Eeyarestatin I - ES1 | ERAD inhibitor 1 | p97 inhibitor 1
3-(4-Chlorophenyl)-4-[[[(4-chlorophenyl)amino]carbonyl]hydroxyamino]-5,5-dimethyl-2-oxo-1-imidazolidineaceticacid2-[3-(5-nitro-2-furanyl)-2-propen-1-ylidene]hydrazide
1-Imidazolidineacetic acid, 3-(4-chlorophenyl)-4-[[[(4-chlorophenyl)amino]carbonyl]hydroxyamino]-5,5-dimethyl-2-oxo-, 2-[3-(5-nitro-2-furanyl)-2-propen-1-ylidene]hydrazide | [Molecular Formula]
C27H25Cl2N7O7 | [MDL Number]
MFCD00319108 | [MOL File]
412960-54-4.mol | [Molecular Weight]
630 |
| Chemical Properties | Back Directory | [density ]
1.49±0.1 g/cm3(Predicted) | [storage temp. ]
2-8°C | [solubility ]
DMSO: soluble5mg/mL | [form ]
Light yellow-orange solid | [pka]
9.13±0.40(Predicted) | [color ]
Yellow to orange | [biological source]
synthetic (organic) | [InChIKey]
JTUXTPWYZXWOIB-UHFFFAOYSA-N | [SMILES]
Clc1ccc(cc1)N2C(C(N(C2=O)CC(=O)NN=CC=Cc4[o]c(cc4)[N+](=O)[O-])(C)C)N(O)C(=O)Nc3ccc(cc3)Cl |
| Hazard Information | Back Directory | [Uses]
Eeyarestatin I is a potent inhibitor of endoplasmic reticulum associated protein degradation. | [Biochem/physiol Actions]
Eeyarestatin I is a potent inhibitor of endoplasmic reticulum associated protein degradation (ERAD). Specifically targets the p97-associated deubiquinating process (PAD) and inhibits ataxin-3 (atx3)-dependent deubiquitination. Also inhibits Sec61-mediated protein translocation at the ER. Displays cytotoxic activity preferentially against cancer cells; induces cell death via the proapoptotic protein NOXA. | [storage]
Store at +4°C |
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Sigma-Aldrich
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NewCan Biotech Limited
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InvivoChem
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