| Identification | More | [Name]
1-AMINO-3,3-DIETHOXYPROPANE | [CAS]
41365-75-7 | [Synonyms]
1-AMINO-3,3-DIETHOXYPROPANE
3,3-DIETHOXY-1-PROPYLAMINE
3-AMINOPROPIONALDEHYDE DIETHYL ACETAL
APEA
RARECHEM AL BW 0123
TIMTEC-BB SBB005781
3,3-Diethoxy-1-propanamine
3,3-Diethoxypropylamine
3,3-Diethoxy-1-aminopropane
3-Amino-1,1-diethoxypropane
3,3-Diethoxypropane-1-amine | [Molecular Formula]
C7H17NO2 | [MDL Number]
MFCD00142581 | [Molecular Weight]
147.22 | [MOL File]
41365-75-7.mol |
| Chemical Properties | Back Directory | [Appearance]
CLEAR COLOURLESS TO YELLOW LIQUID | [Boiling point ]
72 °C (12.0016 mmHg) | [density ]
0.91 g/mL at 25 °C(lit.)
| [refractive index ]
1.4233-1.4253
| [Fp ]
78 °C
| [storage temp. ]
room temp | [solubility ]
Soluble in water, alcohol, and petroleum ether. | [form ]
liquid
| [pka]
8.92±0.13(Predicted) | [color ]
Clear colorless to yellow | [biological source]
synthetic (organic) | [Water Solubility ]
water: miscible | [Sensitive ]
Air Sensitive | [InChI]
InChI=1S/C7H17NO2/c1-3-9-7(5-6-8)10-4-2/h7H,3-6,8H2,1-2H3 | [InChIKey]
PXXMSHBZYAOHBD-UHFFFAOYSA-N | [SMILES]
C(N)CC(OCC)OCC | [CAS DataBase Reference]
41365-75-7(CAS DataBase Reference) |
| Safety Data | Back Directory | [Symbol(GHS) ]
GHS05 | [Signal word ]
Danger | [Hazard statements ]
H314 | [Precautionary statements ]
P280-P303+P361+P353-P304+P340+P310-P305+P351+P338-P363-P405 | [Hazard Codes ]
C | [Risk Statements ]
R34:Causes burns. | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S27:Take off immediately all contaminated clothing .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) . | [RIDADR ]
UN 3267 8/PG 2
| [WGK Germany ]
3
| [HazardClass ]
8 | [PackingGroup ]
I | [HS Code ]
29221985 | [Storage Class]
8A - Combustible corrosive hazardous materials | [Hazard Classifications]
Skin Corr. 1B |
| Hazard Information | Back Directory | [Chemical Properties]
CLEAR COLOURLESS TO YELLOW LIQUID | [Uses]
1-Amino-3,3-diethoxypropane has been used:
- with alginate in the preparation of hydrogel
- in the generation of polyethylene glycol (PEG) polyethylenimine (PEI) polyplexes conjugate for transfection studies in hepatocellular carcinoma cell cultures
- as a component of pH-sensitive PEG derivative for lipopolyplexes formation
| [General Description]
1-Amino-3,3-diethoxypropane is an effective modulator of alginate and chitosan based hydrogels and effectively used for the delivery of bone marrow stromal cells (BMSCs) for regeneration of cartilage. | [Synthesis]
The general procedure for the synthesis of 1-amino-3,3-diethoxypropane from the compound (CAS:107833-73-8) was as follows: 10% Pd/C catalyst (15 mg) was added to a solution of compound 5 (17.7 g, 0.1 mol) in methanol (20 mL), and the reaction was stirred for 12 hr at room temperature and 10 atmospheres of hydrogen atmosphere. After completion of the reaction, the filtrate was filtered through diatomaceous earth and concentrated under reduced pressure to afford compound 6 (14.4 g, 98% yield) as a colorless oil. The product was characterized by 1H NMR (400 MHz, CDCl3): δ = 1.14 (t, 6H, J = 6.8 Hz), 1.29 (br s, 2H), 1.71 (q, 2H, J = 6.4 Hz), 2.73 (t, 2H, J = 6.4 Hz), 3.45 (q, 2H, J = 7.2 Hz), 3.60 (q, 2H, J = 7.2 Hz), 4.53 (t, 1H, J=5.2 Hz). IR (pure sample): 3385,2953,2831,1621,1389 cm-1; mass spectrum (EI): m/z: 147 [M+]. | [References]
[1] Tetrahedron Asymmetry, 2013, vol. 24, # 4, p. 207 - 211 |
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