| Identification | Back Directory | [Name]
16,16-DIMETHYL PROSTAGLANDIN E1 | [CAS]
41692-15-3 | [Synonyms]
16,16-dimethyl PGE1
RQOFITYRYPQNLL-ZWSAOQBFSA-N
16,16-dimethylprostaglandin E
16,16-DIMETHYL PROSTAGLANDIN E1
9-oxo-11α,15R-dihydroxy-16,16-dimethyl-prost-13E-en-1-oic acid
9-OXO-11ALPHA,15R-DIHYDROXY-16,16-DIMETHYL-PROST-13E-EN-1-OIC ACID
Prost-13-en-1-oic acid, 11,15-dihydroxy-16,16-dimethyl-9-oxo-, (11α,13E,15R)-
Prost-13-en-1-oic acid, 11,15-dihydroxy-16,16-dimethyl-9-oxo-, (11alpha,13E,15R)- | [Molecular Formula]
C22H38O5 | [MDL Number]
MFCD00797643 | [MOL File]
41692-15-3.mol | [Molecular Weight]
382.53 |
| Hazard Information | Back Directory | [Description]
16,16-dimethyl PGE1 is a metabolically stable synthetic analog of PGE1. It induces human vascular smooth muscle contractions in vitro. It is 2, 3, and 6 times more potent than PGF2α in contracting tracheal, bronchial, and bronchiolar smooth muscle, respectively.1 | [Uses]
16,16-Dimethylprostaglandin E1 (16,16-dimethyl-PGE1) is a PGE1 (HY-B0131) analog, induces bronchoconstrict and vascular smooth muscle contractions and suppresses the indomethacin induced cellular elongation[1][2][3]. | [Definition]
ChEBI: 16,16-dimethyl-PGE1 is a prostanoid. | [in vivo]
16,16-Dimethylprostaglandin E1 (1 μg/kg?min for 30 min) accelerates blood pressure and heart rate recovery rate, increases catecholamine turnover, enhances levels of epinephrine and norepinephrine in plasma following acute hemorrhage in Sprague Dawley rats[1].
| Animal Model: | Sprague-Dawley rats[1] | | Dosage: | 1 μg/kg?min | | Administration: | 0-30 min | | Result: | Improved blood pressure and heart rate, improved levels of epinephrine and norepinephrine im plasma. |
| [storage]
Store at -20°C | [References]
1. Karim, S.M.M., Adaikan, P.G., and Kottegoda, S.R. Prostaglandins and human respiratory tract smooth muscle: Structure activity relationship Adv. Prostaglandin Thromboxane Res. 7,969-980(1980). |
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