| Identification | Back Directory | [Name]
Glabranin | [CAS]
41983-91-9 | [Synonyms]
Glabranin
Aids095899
Aids-095899
GLABRANIN,99%
Glabranin (flavonoid)
4H-1-Benzopyran-4-one, 2,3-dihydro-5,7-dihydroxy-8-(3-methyl-2-butenyl)-2-phenyl-, (2S)-
4H-1-Benzopyran-4-one, 2,3-dihydro-5,7-dihydroxy-8-(3-methyl-2-buten-1-yl)-2-phenyl-, (2S)- | [Molecular Formula]
C20H20O4 | [MOL File]
41983-91-9.mol | [Molecular Weight]
324.37 |
| Chemical Properties | Back Directory | [Boiling point ]
545.9±50.0 °C(Predicted) | [density ]
1.244±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | [form ]
Powder | [pka]
7.68±0.40(Predicted) | [color ]
White to off-white | [LogP]
6.020 (est) |
| Hazard Information | Back Directory | [Uses]
Glabranine, an flavonoid, is isolated from Tephrosia s.p, exerts a inhibitory effect in vitro on the dengue virus[1].
Glabranine forms interaction with the soluble ectodomain of DENV type 2 (DENV2) E protein[2]. | [Definition]
ChEBI: A dihydroxyflavanone that is pinocembrin substituted by a prenyl group at position 8. | [target]
Antifection | [storage]
Store at -20°C | [References]
[1] Sánchez I, et al. Antiviral effect of flavonoids on the dengue virus. Phytother Res. 2000 Mar;14(2):89-92. DOI:10.1002/(sici)1099-1573(200003)14:23.0.co;2-c
[2] Ismail NA, et al. Molecular Docking and Molecular Dynamics Simulation Studies to Predict Flavonoid Binding on the Surface of DENV2 E Protein. Interdiscip Sci. 2017 Dec;9(4):499-511. DOI:10.1007/s12539-016-0157-8 |
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