| Identification | Back Directory | [Name]
D[LEU4,LYS8]-VP | [CAS]
42061-33-6 | [Synonyms]
D[LEU4,LYS8]-VP
(Deamino-Cys1,Leu?,Lys?)-Vasopressin
MPR-TYR-PHE-LEU-ASN-CYS-PRO-LYS-GLY-NH2
3-Mercaptopropionyl-Tyr-Phe-Leu-Asn-Cys-Pro-Lys-Gly-NH2
Glycinamide, N-(3-mercapto-1-oxopropyl)-L-tyrosyl-L-phenylalanyl-L-leucyl-L-asparaginyl-L-cysteinyl-L-prolyl-L-lysyl-, cyclic (1→5)-disulfide
(Deamino-Cys1,Leu4,Lys8)-Vasopressin trifluoroacetate salt 3-Mercaptopropionyl-Tyr-Phe-Leu-Asn-Cys-Pro-Lys-Gly-NH2 trifluoroacetate salt (Disulfide bond) | [Molecular Formula]
C47H67N11O11S2 | [MDL Number]
MFCD11112200 | [MOL File]
42061-33-6.mol | [Molecular Weight]
1026.24 |
| Chemical Properties | Back Directory | [Boiling point ]
1493.5±65.0 °C(Predicted) | [density ]
1.260±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [form ]
Powder | [pka]
9.90±0.15(Predicted) | [Water Solubility ]
Soluble to 2 mg/ml in water | [Sequence]
{Mpa}-Tyr-Phe-Leu-Asn-Cys-Pro-Lys-Gly (Disulfide bridge:Mpa1-Cys6) |
| Hazard Information | Back Directory | [Uses]
D[LEU4,LYS8]-VP is a selective agonist of vasopressin V1b receptor, with the Kis of 0.16 nM, 0.52 nM, and 0.1.38 nM for rat, human and mouse V1b receptor, respectively. D[LEU4,LYS8]-VP has weak antidiuretic, vasopressor, and in vitro oxytocic activities[1][2]. | [References]
[1] Ana P, et, al. Pharmacological and physiological characterization of d[Leu4, Lys8]vasopressin, the first V1b-selective agonist for rat vasopressin/oxytocin receptors. Endocrinology. 2007 Sep; 148(9): 4136-46. DOI:10.1210/en.2006-1633
[2] Ana P, et, al. Design and synthesis of the first selective agonists for the rat vasopressin V(1b) receptor: based on modifications of deamino-[Cys1]arginine vasopressin at positions 4 and 8. J Med Chem. 2007 Feb 22; 50(4): 835-47. DOI:10.1021/jm060928n |
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