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500170-27-4

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500170-27-4 Structure

500170-27-4 Structure
IdentificationBack Directory
[Name]

(DEAMINO-CYS1,BETA-CYCLOHEXYL-ALA4,ARG8)-VASOPRESSIN
[CAS]

500170-27-4
[Synonyms]

d[Cha4]-AVP
(DeaMino-Cys1,Cha4,Arg8)-Vasopressin
(DeaMino-Cys1,b-cyclohexyl-Ala4,Arg8)-Vasopressin
(Deamino-Cys1,β-cyclohexyl-Ala?,Arg?)-Vasopressin
(DEAMINO-CYS1,BETA-CYCLOHEXYL-ALA4,ARG8)-VASOPRESSIN
3-Mercaptopropionyl-Tyr-Phe-b-cyclohexyl-Ala-Asn-Cys-Pro-Arg-Gly-NH2
3-MERCAPTOPROPIONYL-TYR-PHE-BETA-CYCLOHEXYL-ALA-ASN-CYS-PRO-ARG-GLY-NH2
(Deamino-Cys1,b-cyclohexyl-Ala4,Arg8)-Vasopressin trifluoroacetate salt
3-MERCAPTOPROPIONYL-TYR-PHE-BETA-CYCLOHEXYL-ALA-ASN-CYS-PRO-ARG-GLY-NH2, (DISULFIDE BOND)
Glycinamide, N-(3-mercapto-1-oxopropyl)-L-tyrosyl-L-phenylalanyl-3-cyclohexyl-L-alanyl-L-asparaginyl-L-cysteinyl-L-prolyl-L-arginyl-, cyclic (1→5)-disulfide
[Molecular Formula]

C50H71N13O11S2
[MDL Number]

MFCD08458541
[MOL File]

500170-27-4.mol
[Molecular Weight]

1094.31
Chemical PropertiesBack Directory
[storage temp. ]

Store at RT
[form ]

Solid
[color ]

White to off-white
[Water Solubility ]

Soluble to 1 mg/ml in Water
[Sequence]

{Mpa}-Tyr-Phe-{Cha}-Asn-Cys-Pro-Arg-Gly-NH2 (Disulfide bridge:Mpa1-Cys6)
Hazard InformationBack Directory
[Uses]

d[Cha4]-AVP is a potent and selective vasopressin (AVP) V1b receptor agonist with a Ki of 1.2 nM for human V1b receptor. d[Cha4]-AVP shows more selective for V1b receptor than human V1a receptor, V2 receptor, and oxytocin receptors[1][2].
[References]

[1] Ling Ling Cheng, et al. Design of potent and selective agonists for the human vasopressin V1b receptor based on modifications of [deamino-cys1]arginine vasopressin at position 4. J Med Chem. 2004 Apr 22;47(9):2375-88. DOI:10.1021/jm030611c
[2] Cristiana Griffante, et al. Selectivity of d[Cha4]AVP and SSR149415 at human vasopressin and oxytocin receptors: evidence that SSR149415 is a mixed vasopressin V1b/oxytocin receptor antagonist. Br J Pharmacol. 2005 Nov;146(5):744-51. DOI:10.1038/sj.bjp.0706383
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