| Identification | Back Directory | [Name]
MMRi64 | [CAS]
430458-66-5 | [Synonyms]
MMRi64
MMRi64,MMRi-64
8-Quinolinol, 7-[(2,3-dichlorophenyl)[(4-methyl-2-pyridinyl)amino]methyl]- | [Molecular Formula]
C22H17Cl2N3O | [MOL File]
430458-66-5.mol | [Molecular Weight]
410.3 |
| Chemical Properties | Back Directory | [Boiling point ]
595.5±45.0 °C(Predicted) | [density ]
1.402±0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
4.01±0.50(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
MMRi64 disrupts Mdm2-MdmX interactions. MMRi64 downregulates Mdm2 and MdmX in leukemia cells. MMRi64 induces p53 accumulation, and induces the apoptotic arm of the p53 pathway in leukemia/lymphoma cells. MMRi64 can be used for cancer research[1]. | [References]
[1] Wu W, et al. Targeting RING domains of Mdm2-MdmX E3 complex activates apoptotic arm of the p53 pathway in leukemia/lymphoma cells. Cell Death Dis. 2015 Dec 31;6(12):e2035. DOI:10.1038/cddis.2015.358 |
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