| Identification | Back Directory | [Name]
431884-01-4 | [CAS]
431884-01-4 | [Synonyms]
Antimalarial agent 13
N2-(3-chlorophenyl)-N4-(furan-2-ylmethyl)quinazoline-2,4-diamine
2,4-Quinazolinediamine, N2-(3-chlorophenyl)-N4-(2-furanylmethyl)-
Antimalarial agent13,P. falciparum,Inhibitor,Antimalarial agent 13,inhibit,HepG2,Parasite,Antimalarial agent-13 | [Molecular Formula]
C19H15ClN4O | [MOL File]
431884-01-4.mol | [Molecular Weight]
350.8 |
| Hazard Information | Back Directory | [Uses]
Antimalarial agent 13 (Compound 1) is a potent antimalarial agent. Antimalarial agent 13 shows inhibition with EC50 values of 124 nM and 2.5 μM against P. falciparum parasite and HepG2, respectively[1]. | [References]
[1] Gilson PR, et al. Optimization of 2-Anilino 4-Amino Substituted Quinazolines into Potent Antimalarial Agents with Oral in Vivo Activity. J Med Chem. 2017 Feb 9;60(3):1171-1188. DOI:10.1021/acs.jmedchem.6b01673 |
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