| Identification | More | [Name]
Trimeprazine tartrate | [CAS]
4330-99-8 | [Synonyms]
alimemazine tartrate
n,n,2-trimethyl-3-phenothiazin-10-yl-propan-1-amine tartrate
TRIMEPRAZINE HEMI-(+)-TARTRATE SALT
TRIMEPRAZINE TARTRATE
TRIMEPRAZINE TARTRATE(R)(2:1)
10-(3-(dimethylamino)-2-methylpropyl)phenothiazinetartrate
10-(3-(dimethylamino)-2-methylpropyl)-phenothiazintartrate(2:1)
panectyl
repeltin
temaril
theralene
vallergan
vanectyl
trimeprazine hemi-(+)tartrate
HydroxystilbamidineIsothionate
10H-Phenothiazine-10-propanamine, N,N,β-trimethyl-, (2R,3R)-2,3-dihydroxybutanedioate (2:1)
10H-Phenothiazine-10-propanamine, N,N,β-trimethyl-, [R-(R*,R*)]-2,3-dihydroxybutanedioate (2:1)
NSC 17475
Phenothiazine, 10-[3-(dimethylamino)-2-methylpropyl]-, tartrate (2:1) (8CI)
Temaril 16 | [EINECS(EC#)]
224-368-9 | [Molecular Formula]
C40H50N4O6S2 | [MDL Number]
MFCD00242594 | [Molecular Weight]
746.98 | [MOL File]
4330-99-8.mol |
| Chemical Properties | Back Directory | [Melting point ]
153-155°C | [storage temp. ]
Inert atmosphere,Room Temperature | [solubility ]
DMF: 10 mg/ml; DMSO: 10 mg/ml; Ethanol: 5 mg/ml; PBS (pH 7.2): insol | [form ]
neat | [color ]
White to Almost white | [Merck ]
14,9704 | [Major Application]
pharmaceutical (small molecule) | [InChIKey]
ZEEPCWVFSHMOPI-MVELKYERNA-N | [SMILES]
C(N1C2=CC=CC=C2SC2C=CC=CC1=2)C(C)CN(C)C.[C@H](O)(C(=O)O)[C@@H](O)C(=O)O |&1:21,26,r| | [CAS DataBase Reference]
4330-99-8(CAS DataBase Reference) |
| Safety Data | Back Directory | [Hazard Codes ]
Xn | [Risk Statements ]
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed . | [Safety Statements ]
S36:Wear suitable protective clothing . | [RIDADR ]
3249 | [WGK Germany ]
3 | [RTECS ]
SO6475000 | [HazardClass ]
6.1(b) | [PackingGroup ]
III | [HS Code ]
2934302700 | [Storage Class]
6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects | [Hazard Classifications]
Acute Tox. 3 Oral |
| Hazard Information | Back Directory | [Chemical Properties]
White to Off-White Solid | [Uses]
Antipruritic. Antibacterial, antimicrobial agent | [Brand name]
Temaril (Allergan). | [General Description]
Trimeprazine tartrate, (±)10-[3-(dimethylamino)-2-methylpropyl] phenothiazine tartrate(Temaril), occurs as a white to off-white crystalline powderthat is freely soluble in water and soluble in alcohol. Its antihistaminicaction is reported to be from 1.5 to 5 times thatof promethazine. Clinical studies have shown it has a pronouncedantipruritic action that may be unrelated to itshistamine-antagonizing properties. | [in vivo]
Alimemazine hemitartrate (10 mg/kg, intraperitoneal injection, once a day for 3 weeks) promotes mouse β-cell growth[2].
Alimemazine hemitartrate (10 mg/kg, intraperitoneal injection, once a day for 22 days) synergistically reduces the progression of diabetes in NOD mice[2].
Alimemazine hemitartrate (10 mg/kg, intraperitoneal injection, once a day for 7 days) promotes the proliferation and survival of β-cells in normal mice, but has little effect on β-cell defects caused by IRS2 deficiency[2].
Alimemazine hemitartrate (10 mg/kg, oral gavage, two doses) does not reduce mouse lung virus titers[3]. | Animal Model: | Pdx1+/– mice[2] | | Dosage: | 10 mg/kg, once a day for 3 weeks | | Administration: | Intraperitoneal injection (i.p.) | | Result: | Increased HOMA 2%B and normalized glucose tolerance in mice. |
| Animal Model: | Irs2-/–mice[2] | | Dosage: | 10 mg/kg, once a day for seven days | | Administration: | Intraperitoneal injection (i.p.) | | Result: | Did not restore the function of β cells, but promoted β cell growth and increased the area of β cells in normal mice.
Increased the concentration of IRS2 protein, had no effect on glucose tolerance in mice, and did not change the insulin sensitivity of mice.
|
| Animal Model: | SARS-CoV-2 multiplication in mice[3] | | Dosage: | 10mg/kg, at 1 h prior to and 24 h after virus inoculation | | Administration: | i.g. | | Result: | Did not reduce lung virus titers. |
| [IC 50]
GPCR |
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