| Identification | Back Directory | [Name]
N-(2-Hydroxyethyl)adenosine | [CAS]
4338-48-1 | [Synonyms]
NSC 54251
6-Hydroxyethyladenosine
N-(2-Hydroxyethyl)adenosine
N6-(2-Hydroxyethyl)adenosine
Adenosine, N-(2-hydroxyethyl)-
(2R,3R,4S,5R)-2-(6-((2-Hydroxyethyl)amino)-9H-purin-9-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4
(2R,3R,4S,5R)-2-(6-((2-Hydroxyethyl)amino)-9H-purin-9-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-di
(2R,3R,4S,5R)-2-(6-((2-Hydroxyethyl)aMino)-9H-purin-9-yl)-5-(hydroxyMethyl)tetrahydrofuran-3,4-diol | [EINECS(EC#)]
200-001-2 | [Molecular Formula]
C12H17N5O5 | [MDL Number]
MFCD00056977 | [MOL File]
4338-48-1.mol | [Molecular Weight]
311.29 |
| Chemical Properties | Back Directory | [Melting point ]
194-195℃ | [Boiling point ]
725.8±70.0 °C(Predicted) | [density ]
1.88 | [storage temp. ]
Keep in dark place,Sealed in dry,Room Temperature | [solubility ]
DMSO (Slightly), Methanol (Slightly) | [form ]
Solid | [pka]
13.11±0.70(Predicted) | [color ]
White to Off-White | [InChI]
InChI=1S/C12H17N5O5/c18-2-1-13-10-7-11(15-4-14-10)17(5-16-7)12-9(21)8(20)6(3-19)22-12/h4-6,8-9,12,18-21H,1-3H2,(H,13,14,15)/t6-,8-,9-,12-/m1/s1 | [InChIKey]
BBOCDRLDMQHWJP-WOUKDFQISA-N | [SMILES]
OC[C@H]1O[C@@H](N2C3C(=C(N=CN=3)NCCO)N=C2)[C@H](O)[C@@H]1O |
| Hazard Information | Back Directory | [Uses]
N-(2-Hydroxyethyl)adenosine has been studied as an anticonvulsant through the activation of adenosine A1 receptor (AA1R). | [in vivo]
N6-(2-Hydroxyethyl)adenosine (20-40 mg/kg, ip, once daily for 6 weeks) reduces the blood glucose level and diabetes-induced kidney damage, increases the activities of antioxidant enzymes (such as SOD, catalase CAT and GSH) in renal tissue, reduces the level of malondialdehyde (MDA), exhibits anti-inflammatory and antioxidant activities, and ameliorates Alloxan (HY-W017227)-induced diabetes in rats models[2].
N6-(2-Hydroxyethyl)adenosine (75-150 mg/kg, po, once daily for 19 days) exhibits antitumor effect in SGC-7901 xenograft mouse models[4].
| Animal Model: | Alloxan-induced diabetes in rats models[2] | | Dosage: | 20-40 mg/kg | | Administration: | ip, once daily for 6 weeks | | Result: | Reduced the levels of blood glucose, serum creatinine (Scr), blood urea nitrogen (BUN) and urine protein.
Reduced the levels of TNF-α, IL-1β, IL-6, TGF-β1 and NF-κB in kidney tissue.
Alleviated the damage of glomeruli and renal tubules.
|
| Animal Model: | SGC-7901 xenograft mouse models[4] | | Dosage: | 75-150 mg/kg | | Administration: | po, once daily for 19 days | | Result: | Reduced tumor volume and weight. |
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