| Identification | Back Directory | [Name]
Benzeneacetamide, N-(5-cyclopropyl-1H-pyrazol-3-yl)-α-methyl-4-(2-oxo-1-pyrrolidinyl)-, (αS)- | [CAS]
437982-89-3 | [Synonyms]
Benzeneacetamide, N-(5-cyclopropyl-1H-pyrazol-3-yl)-α-methyl-4-(2-oxo-1-pyrrolidinyl)-, (αS)- | [Molecular Formula]
C19H22N4O2 | [MOL File]
437982-89-3.mol | [Molecular Weight]
338.4 |
| Chemical Properties | Back Directory | [Boiling point ]
722.6±60.0 °C(predicted) | [density ]
1.348±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted) | [pka]
13.43±0.10(predicted) |
| Hazard Information | Back Directory | [Uses]
(S)-PHA533533 is a cyclin-dependent kinase 2 (CDK2) inhibitor. (S)-PHA533533 shows anti-tumor activity and can induce widespread neuronal UBE3A expression in angelman syndrome model mice[1]. | [References]
[1] Vihma H, et al. Ube3a unsilencer for the potential treatment of Angelman syndrome. Nat Commun. 2024 Jul 8;15(1):5558. DOI:10.1038/s41467-024-49788-8 |
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