| Identification | More | [Name]
4-(2-Pyridyl)benzoic acid | [CAS]
4385-62-0 | [Synonyms]
4-(2-PYRIDINYL)BENZOIC ACID
4-(2-PYRIDYL)BENZOIC ACID
4-(PYRIDIN-2-YL)BENZOIC ACID
AKOS BAR-0485
RARECHEM AL BE 0861
4-Pyridin-2-yl-benzoicacid95%
4-(3-Fluoropyridin-2-yl)benzoic acid
4-(4-Chloropyridin-2-yl)benoic acid
4-(4-Fluoropyridin-2-yl)benzoic acid
4-(5-Fluoropyridin-2-yl)benoic acid | [Molecular Formula]
C12H9NO2 | [MDL Number]
MFCD01830093 | [Molecular Weight]
199.21 | [MOL File]
4385-62-0.mol |
| Chemical Properties | Back Directory | [Melting point ]
236.0 to 240.0 °C | [Boiling point ]
388.1±25.0 °C(Predicted) | [density ]
1.241±0.06 g/cm3(Predicted) | [storage temp. ]
2-8°C | [solubility ]
DMSO (Slightly), Methanol (Slightly, Heated) | [form ]
Solid | [pka]
3.17±0.10(Predicted) | [color ]
White to Light Grey | [CAS DataBase Reference]
4385-62-0(CAS DataBase Reference) |
| Hazard Information | Back Directory | [Uses]
Reactive metabolite of Atazanavir (A790051). | [Uses]
Reactive metabolite of Atazanavir (A790051). Atazanavir Impurity (Pyridinyl Benzoic Acid) | [Synthesis]
Example 10: Synthesis of 4-(2-pyridyl)benzoic acid
In a 100 mL jacketed reactor, 200 mL of acetic acid, 0.05 g of manganese(II) acetate, 1.74 g of sulfuric acid, and 3.0 g of 2-(4-methylphenyl)pyridine were sequentially added. The reaction mixture was cooled to 16°C, followed by slow passage of 4.0 g of ozone over 60 minutes. Upon completion of the ozonolysis reaction, the reaction was purged with nitrogen to remove residual ozone from the solvent. The reaction mixture was analyzed by HPLC or GC, which showed that the residue of 2-(4-methylphenyl)pyridine was <0.1% and the yield of 4-(2-pyridyl)benzoic acid was 94-97%. | [References]
[1] Patent: US2003/216577, 2003, A1. Location in patent: Page/Page column 4
[2] Dyes and Pigments, 2017, vol. 140, p. 269 - 277
[3] Dyes and Pigments, 2011, vol. 91, # 3, p. 413 - 421
[4] Journal of the Chemical Society, 1956, p. 100,101
[5] Patent: US5854264, 1998, A |
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