| Identification | Back Directory | [Name]
2,3,4,5-TETRAHYDRO-1H-BENZO[D]AZEPINE | [CAS]
4424-20-8 | [Synonyms]
AKOS BB-9904
BENZ-3-AZEPINE
5-Azabenzocycloheptene
2,3,4,5-Tetrahydro-1H-3-benzazepine
1,2,4,5-tetrahydro-3H-3-benzoazepine
2,3,4,5-TETRAHYDRO-1H-BENZO[D]AZEPINE
1H-3-Benzazepine, 2,3,4,5-tetrahydro-
1,2,4,5-Tetrahydro-3H-benzo[d]azepine
2,3,4,5-Tetrahydro-1H-benzo[d]azepine 90+%
2,3,4,5-Tetrahydro-1H-benzo[d]azepinemin.90%
2,3,4,5-TETRAHYDRO-1H-BENZO[D]AZEPINE HYDROCHLORIDE
2,3,4,5-TETRAHYDRO-1H-BENZO[D]AZEPINE
BENZ-3-AZEPINE | [EINECS(EC#)]
807-686-8 | [Molecular Formula]
C10H13N | [MDL Number]
MFCD04012620 | [MOL File]
4424-20-8.mol | [Molecular Weight]
147.22 |
| Questions And Answer | Back Directory | [Synthesis]
1,2-Phenylacetonitrile was dissolved in 150 mL of DMF, and 15.86 g (142 mmol) of potassium tert-butoxide was added at an internal temperature of -10 to 0 °C. The mixture was stirred at 0–5 °C for 2 h. Then, 200 mL of water and 22 mL of 30% hydrochloric acid were added at 0–5 °C, and the mixture was stirred for 1 h. The mixture was filtered to obtain a crude product, which was then dissolved in 170 mL of methanol and recrystallized. After filtration and drying, 20.87 g of 2,3,4,5-TETRAHYDRO-1H-BENZO[D]AZEPINE was obtained, with a yield of 89%. |
| Chemical Properties | Back Directory | [Boiling point ]
110-120℃ (11 Torr) | [density ]
0.981±0.06 g/cm3 (20 ºC 760 Torr) | [refractive index ]
1.565 (589.3 nm 20℃) | [Fp ]
114.9±14.2℃ | [storage temp. ]
Keep in dark place,Inert atmosphere,Room temperature | [solubility ]
DMSO (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly) | [form ]
liquid | [pka]
10.27±0.20(Predicted) | [color ]
Clear, brown | [InChI]
InChI=1S/C10H13N/c1-2-4-10-6-8-11-7-5-9(10)3-1/h1-4,11H,5-8H2 | [InChIKey]
MWVMYAWMFTVYED-UHFFFAOYSA-N | [SMILES]
N1CCC2=CC=CC=C2CC1 | [CAS DataBase Reference]
4424-20-8 |
| Hazard Information | Back Directory | [Uses]
5-Azabenzocycloheptene is a reactant used in the synthesis of nonretinoid retinol binding protein 4 antagonists for potential treatment of atrophic age-related macular degeneration and Stargardt disease. |
|
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J & K SCIENTIFIC LTD.
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