| Identification | Back Directory | [Name]
Isopedicin | [CAS]
4431-42-9 | [Synonyms]
Isopedicin
6-Hydroxy-5,7,8-trimethoxyflavanone
4H-1-Benzopyran-4-one, 2,3-dihydro-6-hydroxy-5,7,8-trimethoxy-2-phenyl-, (2S)- | [Molecular Formula]
C18H18O6 | [MDL Number]
MFCD23103659 | [MOL File]
4431-42-9.mol | [Molecular Weight]
330.33 |
| Hazard Information | Back Directory | [Uses]
Isopedicin potently and concentration-dependently inhibits superoxide anion (O2 U?) production in formyl-L-methionyl-L-leucyl-L-phenylalanine (FMLP)-activated cells. Isopedicin increases cAMP formation and PKA activity in FMLP-activated cells by inhibiting phosphodiesterase (PDE) activity[1]. | [References]
[1] Hwang TL, et al. Potent inhibition of superoxide anion production in activated human neutrophils by isopedicin, a bioactive component of the Chinese medicinal herb Fissistigma oldhamii. Free Radic Biol Med. 2009 Feb 15;46(4):520-8. DOI:10.1016/j.freeradbiomed.2008.11.014 |
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