| Identification | Back Directory | [Name]
TP 235 | [CAS]
443104-02-7 | [Synonyms]
TP 235
CPD1598
CDDO-IM
RTA 403
CDDO IMidazolide
CDDO-Im (RTA-403)
CDDO-Im, RTA 403, TP 235
2-Cyano-3,12-dioxooleana-1,9(11)-dien-28-oic acid iMidazolide
1-(2-Cyano-3,12,28-trioxooleana-1,9(11)-dien-28-yl)-1H-iMidazole
1H-Imidazole, 1-(2-cyano-3,12,28-trioxooleana-1,9(11)-dien-28-yl)-
(4aR,6aR,6aS,6bR,8aS,12aS,14bS)-8a-(imidazole-1-carbonyl)-4,4,6a,6b,11,11,14b-heptamethyl-3,13-dioxo-4a,5,6,6a,7,8,9,10,12,12a-decahydropicene-2-carbonitrile | [Molecular Formula]
C34H43N3O3 | [MDL Number]
MFCD12756341 | [MOL File]
443104-02-7.mol | [Molecular Weight]
541.72 |
| Chemical Properties | Back Directory | [Melting point ]
>164°C (dec.) | [Boiling point ]
681.8±65.0 °C(Predicted) | [density ]
1.23±0.1 g/cm3(Predicted) | [storage temp. ]
Sealed in dry,2-8°C | [solubility ]
Chloroform (Slightly), Methanol (Very Slightly, Heated) | [form ]
Solid | [pka]
3.47±0.10(Predicted) | [color ]
Pale Yellow to Very Dark Yellow | [Stability:]
Light Sensitive | [InChIKey]
ITFBYYCNYVFPKD-FMIDTUQUSA-N | [SMILES]
[n]6(cncc6)C(=O)[C@]21[C@H]([C@@H]3[C@]([C@@]4(CC[C@@H]5[C@@](C4=CC3=O)(C=C(C(=O)C5(C)C)C#N)C)C)(CC2)C)CC(CC1)(C)C |
| Hazard Information | Back Directory | [Chemical Properties]
Pale Yellow Solid | [Uses]
CDDO Imidozolide (CDDO-Im) is a synthetic triterpenoid CDDO-Im inhibits fatty acid synthase expression and has antiproliferative and proapoptotic effects in human liposarcoma cells. Studies show that
CDDO-Im is highly active in suppressing cellular proliferation of human leukemia and breast cancer cell lines as well as being an effective therapeutic agent in the treatment of other types of cancers
. | [Biological Activity]
CDDO-Im is a bifunctional CDDO analog th at enhances NRF2-mediated antioxidant and anti-inflammatory activity by forming not only KEAP1 covalent adducts (Michael adducts via cysteinesacyl adducts via lysines and tyrosines) in the same manner as CDDO and CDDO-Mebut also by covalently transacylating arginine and serine residues in GSTP and cross-linking them to adjacent cysteine residues. CDDO-Im is typically used in the range of 1-40 nM in cultures2-5.5 mg/kg via i.p. and 2.5 mg/kg via i.v. in vivo (mice and rats). | [in vivo]
CDDO-Im is a potent inhibitor of de novo inducible nitric oxide synthase expression in primary mouse macrophages. Moreover, CDDO-Im inhibits growth of B16 murine melanoma and L1210 murine leukemia cells in vivo. Injection of 10 nM (5.4 μg) of CDDO-Im almost completely blocks the ability of IFN-γ to induce iNOS, and treatment with as little as 1 nmol of CDDO-Im (0.54 μg) is partially effective[1]. | [IC 50]
PPARα: 232 nM (Ki); PPARγ: 344 nM (Ki); Nrf2 | [storage]
Store at RT |
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| Company Name: |
SPIRO PHARMA
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| Tel: |
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| Website: |
www.spiropharma.com.cn |
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