| Identification | Back Directory | [Name]
NU6140 | [CAS]
444723-13-1 | [Synonyms]
NU6140
4-[[6-(Cyclohexylmethoxy)-1H-purin-2-yl]amino]-N,N-diethylbenzamide
4-[[6-(cyclohexylmethoxy)-7H-purin-2-yl]amino]-N,N-diethylbenzamide
Benzamide, 4-[[6-(cyclohexylmethoxy)-9H-purin-2-yl]amino]-N,N-diethyl- | [Molecular Formula]
C23H30N6O2 | [MDL Number]
MFCD09264153 | [MOL File]
444723-13-1.mol | [Molecular Weight]
422.52 |
| Chemical Properties | Back Directory | [Boiling point ]
707.8±70.0 °C(Predicted) | [density ]
1.234±0.06 g/cm3(Predicted) | [storage temp. ]
Desiccate at +4°C | [solubility ]
DMF: 30 mg/ml; DMSO: 30 mg/ml; Ethanol: 30 mg/ml; Ethanol:PBS (pH 7.2) (1:3): 0.25 mg/ml | [form ]
White to off-white solid. | [pka]
9.41±0.10(Predicted) | [color ]
White to light yellow | [InChI]
1S/C23H30N6O2/c1-3-29(4-2)22(30)17-10-12-18(13-11-17)26-23-27-20-19(24-15-25-20)21(28-23)31-14-16-8-6-5-7-9-16/h10-13,15-16H,3-9,14H2,1-2H3,(H2,24,25,26,27,28) | [InChIKey]
XHEQSRJCJTWWAH-UHFFFAOYSA-N | [SMILES]
O=C(N(CC)CC)C1=CC=C(NC2=NC(NC=N3)=C3C(OCC4CCCCC4)=N2)C=C1 |
| Hazard Information | Back Directory | [Uses]
NU 6140 is a cyclin-dependant kinase 2 inhibitor which demonstrates 10-36 fold selectivity against Cdk2-cyclin A. This selectivity induces cell-cycle arrest at the G2-M phase and potentiates the apoptotic effect of pacitaxel. | [Biological Activity]
NU6140 is a CDK2 inhibitor with 10-36-fold selectivity over other CDK family members. NU6140 induces apoptosis and cell cycle arrest in cancer cells in the G2-M phaseand potentiates the cytotoxic effects of paclitaxel.''NU6140 is known to downregulate the expression of survivin proteinwhich possesses antiapoptotic activity and is generally overexpressed in cancer cells. | [IC 50]
cdk2-cyclin A: 0.41 μM (IC50); CDK1-Cyclin B: 6.6 μM (IC50); CDK4-Cyclin D: 5.5 μM (IC50); cdk5-p25: 15 μM (IC50); cdk7-cyclin H: 3.9 μM (IC50); Aurora A: 67 nM (IC50); Aurora B: 35 nM (IC50) | [storage]
Desiccate at +4°C |
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| Company Name: |
Energy Chemical
|
| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
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