ChemicalBook--->CAS DataBase List--->444912-48-5

444912-48-5

444912-48-5 Structure

444912-48-5 Structure
IdentificationBack Directory
[Name]

(R,S)-AM1241
[CAS]

444912-48-5
[Synonyms]

(R,S)-AM1241
AM1241 (AM-1241
(R,S)-AM1241 USP/EP/BP
(R,S)-3-(2-Iodo-5-nitrobenzoyl)-1-(1-methyl-2-piperidinylmethyl)-1H-indole
(3-iodo-5-nitrophenyl)-[1-[(1-methylpiperidin-2-yl)methyl]indol-3-yl]methanone
(2-iodo-5-nitrophenyl)-[1-[(1-methylpiperidin-2-yl)methyl]indol-3-yl]methanone
(2-Iodo-5-nitrophenyl)[1-[(1-methyl-2-piperidinyl)methyl]-1H-indol-3-yl]methanone
(2-Iodo-5-nitrophenyl)(1-((1-methylpiperidin-2-yl)methyl)-1H-Indol-3-yl)methanone
Methanone, (2-iodo-5-nitrophenyl)[1-[(1-methyl-2-piperidinyl)methyl]-1H-indol-3-yl]-
[Molecular Formula]

C22H22IN3O3
[MDL Number]

MFCD11045986
[MOL File]

444912-48-5.mol
[Molecular Weight]

503.34
Chemical PropertiesBack Directory
[Boiling point ]

630.7±55.0 °C(Predicted)
[density ]

1.60±0.1 g/cm3(Predicted)
[storage temp. ]

Store at -20°C
[solubility ]

DMSO: ~18mg/mL at 60°C
[form ]

solid
[pka]

9.73±0.10(Predicted)
[color ]

yellow
Safety DataBack Directory
[Hazard Codes ]

Xn
[Risk Statements ]

36/37/38-42/43
[Safety Statements ]

22-26-36/37-45
[WGK Germany ]

3
Hazard InformationBack Directory
[Description]

AM1241 is a cannabinoid (CB) receptor agonist that is selective for CB2 over CB1 with Ki values of 7.1 and 580 nM for human recombinant receptors transfected into HEK and CHO cells, respectively, in a radioligand binding assay. It is considered a protean agonist as it has neutral antagonist and partial agonist activity, depending on the assay utilized. It is also acts in a species-dependent manner in vitro, acting as an agonist at human CB2 receptors (EC50 = 190 nM) but an inverse agonist at rat and mouse CB2 receptors (EC50s = 216 and 463 nM, respectively). AM1241 produces antinociception to thermal stimuli in rat hindpaw. The antinociceptive actions of AM1241 were blocked by the CB2 receptor-selective antagonist AM630 but not by the CB1 receptor-selective antagonist AM251 . AM1241 is neuroprotective, preventing HIV-1 glycoprotein Gp120-induced apoptosis in primary human and murine neural progenitor cells and increasing cell survival and differentiation. It increases hippocampal neurogenesis and decreases astro- and gliogenesis in GFAP/Gp120 transgenic mice when administered at a dose of 10 mg/kg daily for ten days. AM1241 also delays motor impairment in a murine model of amytrophic lateral sclerosis (ALS).
[Uses]

(2-Iodo-5-nitrophenyl)[1-[(1-methyl-2-piperidinyl)methyl]-1H-indol-3-yl]methanone is a compound from the aminkalkylindole family which exerts potent and selective agonist activity for the cannabinoid receptor CB2.
[Biological Activity]

Potent and selective CB2 receptor agonist (Ki=3.4nM (mouse), Ki=280nM (rat) also in vivo.
[Biochem/physiol Actions]

AM1241 acts as an antinociceptive agent in several animal pain models. It has a potential to delay disease progression in amyotrophic lateral sclerosis (ALS) mouse model. Intrathecal, intravenous or intraperitoneal administration of AM1241 reduces hyperalgesia and allodynia in neuropathic rats.
[target]

CB2
444912-48-5 suppliers list
Company Name: ATK CHEMICAL COMPANY LIMITED
Tel: +undefined-21-51877795
Website: www.atkchemical.com
Company Name: Hubei xin bonus chemical co. LTD
Tel: 86-13657291602
Website: www.chemicalbook.com/ShowSupplierProductsList1549548/0.htm
Company Name: CONIER CHEM AND PHARMA LIMITED
Tel: +8618523575427 , +8618523575427
Website: http://www.conier.com/
Company Name: Dideu Industries Group Limited
Tel: +86-29-89586680 +86-15129568250 , +86-15129568250
Website: www.dideu.com
Company Name: InvivoChem
Tel: +1-708-310-1919 +1-13798911105 , +1-13798911105
Website: https://www.invivochem.com/
Company Name: TargetMol Chemicals Inc.
Tel: +1-781-999-5354
Website: https://www.targetmol.com/
Company Name: Aladdin Scientific
Tel: +1-833-552-7181
Website: https://www.aladdinsci.com/
Company Name: Amadis Chemical Company Limited
Tel: 571-89925085
Website: http://www.amadischem.com
Company Name: China DongFan Chemical Co.,LTD  
Tel: 86-0571-85151182
Website: www.chemicalbook.com/ShowSupplierProductsList14819/0.htm
Company Name: NCE Biomedical Co.,Ltd.  
Tel: 4000-027-021 |24 +86-13986109188 | +86-15623472865 | +81-08033611988
Website: www.chemicalbook.com/ShowSupplierProductsList15748/0.htm
Company Name: Shanghai Aladdin Bio-Chem Technology Co.,LTD  
Tel: 18521735133 18521732826;
Website: http://www.aladdin-e.com/
Company Name: Hubei Jusheng Technology Co.,Ltd  
Tel: 027-59599241 18871490274
Website: www.jushengtech.com
Company Name: LETOPHARM LIMITED  
Tel: +86-21-5821 5861
Website: www.letopharm.com
Company Name: Sigma-Aldrich  
Tel: 021-61415566 800-8193336
Website: https://www.sigmaaldrich.cn
Company Name: SPIRO PHARMA  
Tel:
Website: www.spiropharma.com.cn
Company Name: Codow Chemical Co.,Ltd.  
Tel: 18620099427
Website: www.howeipharm.com
Company Name: Shanghai EFE Biological Technology Co., Ltd.  
Tel: 021-65675885 18964387627
Website: http://www.efebio.com
Company Name: Chengdu Dianchun Technology Co., Ltd  
Tel: 400-1166-196 18502815961
Website: www.hx-r.com
Tags:444912-48-5 Related Product Information
170729-80-3 1032350-13-2 503612-47-3 208255-80-5 85622-93-1 877399-52-5