| Identification | Back Directory | [Name]
(R)-AM1241 | [CAS]
444912-51-0 | [Synonyms]
(R)-AM1241
(R)-AM1241 Exclusive
ZUHIXXCLLBMBDW-MRXNPFEDSA-N
(R) AM1241,(R)-AM-1241,(R)AM1241 | [Molecular Formula]
C22H22IN3O3 | [MDL Number]
MFCD06798331 | [MOL File]
444912-51-0.mol | [Molecular Weight]
503.33 |
| Chemical Properties | Back Directory | [Boiling point ]
630.7±55.0 °C(Predicted) | [density ]
1.60±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMF: 25 mg/ml; DMF:PBS(pH7.2) (1:2): 0.3 mg/ml; DMSO: 10 mg/ml; Ethanol: 5 mg/ml | [pka]
9.73±0.10(Predicted) |
| Hazard Information | Back Directory | [Description]
(R)-AM1241 binds to cannabinoid (CB) receptors and has greater than 100-fold selectivity for the CB2 over the CB1 receptor (Kis = 15 and 5,000 nM, respectively, in a membrane assay using human receptors). (R)-AM1241 acts as an agonist at human CB2 receptors (EC50 = 118 nM) but an inverse agonist at rat and mouse CB2 receptors (EC50s = 315 and 341 nM, respectively). Similar to the racemate AM1241 , (R)-AM1241 produces antinociception to thermal, but not mechanical, pain in rats. The pain-reducing effect of (R)-AM1241 is blocked by the CB2-specific inhibitor SR 144528 but not by either the CB1-selective inhibitor rimonabant or the opioid receptor blocker naloxone ( | ISO60191). | [Uses]
(R)-AM1241 binds to cannabinoid (CB) receptors and has greater than 100-fold selectivity for the CB2 over the CB1 receptor. Synthetic cannabinoid.Synthetic Cannabinoids | [storage]
Store at -20°C | [References]
[1] B BINGHAM. Species-specific in vitro pharmacological effects of the cannabinoid receptor 2 (CB2) selective ligand AM1241 and its resolved enantiomers[J]. British Journal of Pharmacology, 2009, 151 7: 1137. DOI: 10.1038/sj.bjp.0707378
[2] ELIZABETH J RAHN. Antinociceptive effects of racemic AM1241 and its chirally synthesized enantiomers: lack of dependence upon opioid receptor activation.[J]. AAPS Journal, 2010, 12 2: 147-157. DOI: 10.1208/s12248-009-9170-8
[3] MARJOLEIN SOETHOUDT. Cannabinoid CB2 receptor ligand profiling reveals biased signalling and off-target activity.[J]. ACS Combinatorial Science, 2017: 13958. DOI: 10.1038/ncomms13958 |
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