| Identification | More | [Name]
2-FLUOROBENZHYDRAZIDE | [CAS]
446-24-2 | [Synonyms]
2-FLUOROBENZHYDRAZIDE
2-FLUOROBENZOHYDRAZIDE
2-FLUOROBENZOIC ACID HYDRAZIDE
2-FLUOROBENZOIC HYDRAZIDE
2-FLUOROBENZOYLHYDRAZINE
AKOS BBS-00004507
BUTTPARK 35\03-71
O-FLUOROBENZHYDRAZIDE
2-Fluorobenzhydrazide,97%
2-Fluorobenzhydrazide,99%
o-Fluorobenzohydrazide
2 flurobenzhydrazide
2-Fluorobenzhydrazide 98%
2-Fluorobenzhydrazide98% | [Molecular Formula]
C7H7FN2O | [MDL Number]
MFCD00025112 | [Molecular Weight]
154.14 | [MOL File]
446-24-2.mol |
| Chemical Properties | Back Directory | [Melting point ]
70-74 °C (lit.) | [storage temp. ]
Keep in dark place,Inert atmosphere,Room temperature | [solubility ]
soluble in Methanol | [form ]
Powder or Crystalline Powder | [color ]
White to pale brown | [InChI]
1S/C7H7FN2O/c8-6-4-2-1-3-5(6)7(11)10-9/h1-4H,9H2,(H,10,11) | [InChIKey]
YJCCKQQVXNNAAR-UHFFFAOYSA-N | [SMILES]
NNC(=O)c1ccccc1F | [CAS DataBase Reference]
446-24-2(CAS DataBase Reference) |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing . | [WGK Germany ]
3
| [Hazard Note ]
Irritant | [HazardClass ]
IRRITANT | [HS Code ]
2928009090 | [Storage Class]
11 - Combustible Solids | [Hazard Classifications]
Eye Irrit. 2
Skin Irrit. 2
STOT SE 3 |
| Hazard Information | Back Directory | [Synthesis Reference(s)]
Journal of Heterocyclic Chemistry, 26, p. 257, 1989 DOI: 10.1002/jhet.5570260147 | [Synthesis]
GENERAL METHODS: 2-Fluorophenylidene hydrazine was synthesized routinely by one-pot method (30-58% yield). Ethyl o-fluorobenzoate (10 mmol) was dissolved in ethanol (20 mL). 3N sulfuric acid (2 mL) was added to the solution, followed by refluxing the reaction mixture for 6 hours. The reaction process was monitored by thin layer chromatography (TLC). Upon completion of the reaction, the reaction mixture was neutralized with solid NaHCO3 and excess NaHCO3 was removed by filtration.To the neutralized reaction mixture, hydrazine monohydrate (1.5 mL, 3 mmol) was added and refluxing was continued for 3-6 h to ensure complete reaction. The ethanol and unreacted hydrazine monohydrate were concentrated to 1/3 of the original volume by distillation.The reaction mixture was cooled to room temperature, the resulting solid was filtered and recrystallized from methanol to give crystals of the target product, 2-fluorophenylidenehydrazine (see Supporting Information for specific data). | [References]
[1] Bioorganic and Medicinal Chemistry, 2015, vol. 23, # 17, p. 6014 - 6024
[2] Journal of the American Chemical Society, 1950, vol. 72, p. 1806
[3] Journal of Agricultural and Food Chemistry, 2003, vol. 51, # 1, p. 152 - 155
[4] Bioorganic and Medicinal Chemistry Letters, 2006, vol. 16, # 8, p. 2278 - 2282
[5] Journal of Medicinal Chemistry, 2010, vol. 53, # 20, p. 7392 - 7404 |
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https://www.jkchemical.com |
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Alfa Aesar
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400-6106006 |
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http://chemicals.thermofisher.cn |
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Energy Chemical
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400-0056266 |
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www.energy-chemical.com |
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