| Identification | Back Directory | [Name]
NS1643 | [CAS]
448895-37-2 | [Synonyms]
NS1643, >98%
NS-1643;NS 1643
NS-1643;NS1643;NS 1643
N,N'-Bis[2-hydroxy-5-(trifluoromethyl)phenyl]urea
Urea, N,N'-bis[2-hydroxy-5-(trifluoromethyl)phenyl]- | [Molecular Formula]
C15H10F6N2O3 | [MDL Number]
MFCD08705418 | [MOL File]
448895-37-2.mol | [Molecular Weight]
380.24 |
| Chemical Properties | Back Directory | [Boiling point ]
342.3±42.0 °C(Predicted) | [density ]
1.626±0.06 g/cm3(Predicted) | [storage temp. ]
Inert atmosphere,2-8°C | [solubility ]
DMSO: ≥20mg/mL | [form ]
solid | [pka]
6.84±0.13(Predicted) | [color ]
white to off-white |
| Hazard Information | Back Directory | [Uses]
NS 1643 is a human ether-a-go-go-related gene 1 potassium channel (KCNH2) activator. | [Biological Activity]
Human ether-a-go-go related gene (hERG) K + channel activator (EC 50 = 10.5 μ M). Exhibits different molecular mechanisms of action at hERG1 and hERG2 channels. Displays antiarrhythmic activity in vitro . | [in vivo]
NS1643 (6 mg/kg; i.p., twice per week) inhibits breast tumor metastasis[2]. | Animal Model: | NSG mice with human-derived TNBC tumor xenografts[2] | | Dosage: | 6 mg/kg | | Administration: | Intraperitoneal injection; 6 mg/kg; twice per week | | Result: | Significantly reduceed tumor
growth and the metastatic liver tumors were significantly smaller than those in the control group. Decreased levels of human nuclear antigen (HNA).
|
| [storage]
+4°C |
|
| Company Name: |
J & K SCIENTIFIC LTD.
|
| Telephone: |
18210857532 18210857532 |
| Website: |
https://www.jkchemical.com |
| Company Name: |
SynAsst Chemical.
|
| Telephone: |
021-60343070 |
| Website: |
www.chemicalbook.com/ShowSupplierProductsList15848/0_EN.htm |
|