| Identification | Back Directory | [Name]
PNU 37883 hydrochloride | [CAS]
57568-80-6 | [Synonyms]
U-37883A
PNU 37883 hydrochlor
PNU 37883 HYDROCHLORIDE
N-CYCLOHEXYL-N'-TRICYCLO[3.3.1.1(3,7)]DEC-1-YL-4-MORPHOLINECARBOXIMIDAMIDE HYDROCHLORIDE | [Molecular Formula]
C21H36ClN3O | [MDL Number]
MFCD03840615 | [MOL File]
57568-80-6.mol | [Molecular Weight]
381.98 |
| Hazard Information | Back Directory | [Uses]
PNU 37883 hydrochloride (PNU 37883A) is a selective vascular ATP-sensitive potassium (Kir6, KATP) channels blocker. PNU 37883 hydrochloride has diuretic effects with specific binding in kidney and vascular smooth muscle rather than in brain or pancreatic beta cells[1][2]. | [Biological Activity]
Novel antagonist selective for the vascular form of K ATP channel; inhibits K ATP currents in isolated mesenteric artery smooth muscle cells (K d = 65 nM) but not in cardiac or skeletal myocytes. In vivo, inhibits blood vessel relaxation and hypotension induced by pinacidil. Displays weak diuretic effects. | [storage]
Desiccate at RT | [References]
[1] Yi Cui, et al. Different molecular sites of action for the KATP channel inhibitors, PNU-99963 and PNU-37883A. Br J Pharmacol. 2003 May;139(1):122-8. DOI:10.1038/sj.bjp.0705228
[2] Noriyoshi Teramoto. Pharmacological Profile of U-37883A, a Channel Blocker of Smooth Muscle-Type ATP-Sensitive K Channels. Cardiovasc Drug Rev. Spring 2006;24(1):25-32. DOI:10.1111/j.1527-3466.2006.00025.x
[3] Guang-Yuan Mar, et al. Changes of imidazoline receptors in spontaneously hypertensive rats. Int J Exp Pathol. 2013 Feb;94(1):17-24. DOI:10.1111/iep.12000 |
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