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448954-98-1

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448954-98-1 Structure

448954-98-1 Structure
IdentificationBack Directory
[Name]

6-Aminooxy-hexanoic acid
[CAS]

448954-98-1
[Synonyms]

hydrobromide, 10 mg
hydrobromide, 100 mg
HBr.H2N-O-(CH2)5-COOH
6-Aminooxy-hexanoic acid
NH2-O-C5-COOH hydrobromide
6-Aminooxy-hexanoic acid, HBr
6-Aminooxy-hexanoic acid,hydrobromide
6-Aminooxy-hexamoic acid hydrobromide
[Molecular Formula]

C6H13NO3.BrH
[MDL Number]

MFCD09743539
[MOL File]

448954-98-1.mol
[Molecular Weight]

228.09
Hazard InformationBack Directory
[Uses]

NH2-O-C5-COOH (hydrobromide) is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1].
[Biological Activity]

NH2-O-C5-COOH (hydrobromide) is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
[IC 50]

Alkyl-Chain
[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562
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