| Identification | Back Directory | [Name]
BOC-D-ABU-OH | [CAS]
45121-22-0 | [Synonyms]
BOC-D-ABU
BOC-D-ABU-OH
BOC-D-2-ABU-OH
BOC-D-ABU(2)-OH
BOC-D-ALPHA-ABU-OH
BOC-D-ABU(ALPHA)-OH
BOC-D-ABU-OH USP/EP/BP
BOC-D-NHCH(CH2CH3)-COOH
BOC-D-AMINOBUTYRIC ACID
BOC-D-2-AMINOBUTYRIC ACID
Boc-D-a-aminobutyric acid
BOC-D-2-ABU-OH, 45121-22-0
BOC-D-2-AMINOBUTANOIC ACID
BOC-(R)-2-aminobutyric acid
(R)-Boc-2-aMinobutyric acid
N-Boc-D-2-aMinobutyric acid
(R)-N-Boc-2-aminobutyric acid
BOC-D-ALPHA-AMINOBUTYRIC ACID
BOC-D-2-Aminobutyric acid dicy
(Tert-Butoxy)Carbonyl D-Abu-OH
(R)-2-(Boc-amino)butyricacid,95%
(R)-2-(Boc-aMino)butyric acid, 95%
Boc-D-a-aminobutyric acid≥ 98% (HPLC)
Boc-D-2-aminobutanoic acid sodium salt
2-(R)-tert-Butoxycarbonylaminobutyric acid
N-ALPHA-T-BUTOXYCARBONYL-D-2-AMINO-BUTYRIC ACID
(R)-2-((tert-Butoxycarbonyl)aMino)butanoic acid
(2R)-2-[[(tert-Butoxy)carbonyl]amino]butanoic acid
N-ALPHA-T-BUTOXYCARBONYL-D-ALPHA-AMINOBUTANOIC ACID
(2R)-2-[(2-methylpropan-2-yl)oxycarbonylamino]butanoicaci
(2R)-2-[(2-methylpropan-2-yl)oxycarbonylamino]butanoic acid
Butanoic acid, 2-[[(1,1-dimethylethoxy)carbonyl]amino]-, (2R)- | [Molecular Formula]
C9H17NO4 | [MDL Number]
MFCD00270335 | [MOL File]
45121-22-0.mol | [Molecular Weight]
203.24 |
| Chemical Properties | Back Directory | [Boiling point ]
334.5±25.0 °C(Predicted) | [density ]
1.101 | [storage temp. ]
Store at RT. | [solubility ]
Soluble in DMF (1mmol in 1ml DMF). | [form ]
Liquid | [pka]
4.00±0.10(Predicted) | [color ]
Yellow |
| Hazard Information | Back Directory | [Chemical Properties]
White powder | [Uses]
(R)-2-(Boc-amino)butyric acid is used in coupling reaction. Also used in preparation of dyes. | [Synthesis]
[Step 1] Synthesis of (R)-2-((tert-butoxycarbonyl)amino)butanoic acid
Di-tert-butyl dicarbonate (4.7 g, 21 mmol) was slowly added to a mixed solution of (R)-2-aminobutyric acid (2.0 g, 19 mmol) and sodium bicarbonate (1.6 g, 19 mmol) in a mixture of 1,4-dioxane and water (3:10 v/v/v, total 26 mL) under ice bath cooling. The reaction mixture was stirred at room temperature for 120 hours and then concentrated under reduced pressure. The resulting crude product was dissolved in chloroform, to which 1N hydrochloric acid was subsequently added and extracted with chloroform. The organic layer was dried over anhydrous sodium sulfate and concentrated under reduced pressure to give 2.0 g (quantitative yield) of the title compound (hereinafter referred to as Reference Example Compound 27). | [References]
[1] Patent: EP2832724, 2015, A1. Location in patent: Paragraph 0169
[2] European Journal of Organic Chemistry, 2002, # 23, p. 3995 - 4004
[3] Journal of the American Chemical Society, 1997, vol. 119, # 4, p. 656 - 673
[4] Bioorganic and Medicinal Chemistry Letters, 1999, vol. 9, # 22, p. 3237 - 3242
[5] Tetrahedron, 2006, vol. 62, # 42, p. 9966 - 9972 |
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