| Identification | More | [Name]
3-FLUORO-4-METHOXYPHENYLACETIC ACID | [CAS]
452-14-2 | [Synonyms]
3-FLUORO-4-METHOXYPHENYLACETIC ACID
RARECHEM AL BO 1534
3-Fluoro-4-methyloxyphenylaceticacid
3-Fluoro-4-methoxyphenylacetic acid 98%
3-Fluoro-4-methoxyphenylaceticacid98%
2-(3-fluoro-4-methoxyphenyl)acetic acid | [Molecular Formula]
C9H9FO3 | [MDL Number]
MFCD00060353 | [Molecular Weight]
184.16 | [MOL File]
452-14-2.mol |
| Chemical Properties | Back Directory | [Melting point ]
111-113°C | [Boiling point ]
309.0±27.0 °C(Predicted) | [density ]
1.269±0.06 g/cm3(Predicted) | [storage temp. ]
Store below +30°C. | [form ]
powder | [pka]
4.25±0.10(Predicted) | [color ]
White to off-white | [InChI]
1S/C9H9FO3/c1-13-8-3-2-6(4-7(8)10)5-9(11)12/h2-4H,5H2,1H3,(H,11,12)/p-1 | [InChIKey]
VURNBRZIFABCRU-UHFFFAOYSA-M | [SMILES]
Fc1c(ccc(c1)CC(=O)[O-])OC | [CAS DataBase Reference]
452-14-2(CAS DataBase Reference) |
| Safety Data | Back Directory | [Symbol(GHS) ]
GHS05 | [Signal word ]
Danger | [Hazard statements ]
H318 | [Precautionary statements ]
P280-P305+P351+P338 | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection . | [WGK Germany ]
WGK 1 | [Hazard Note ]
Irritant | [HazardClass ]
IRRITANT | [HS Code ]
2918290090 | [Storage Class]
11 - Combustible Solids | [Hazard Classifications]
Eye Dam. 1 |
| Hazard Information | Back Directory | [Synthesis]
3-fluoro-4-methoxyphenylacetonitrile (42 g, 0.25 mol) was heated for 5 h with 32 g of potassium hydroxide solution in 120 mL of ethanol and 30 mL of water. After the distillation of ethanol, the residue was diluted with water to a volume of 175 mL. The solution was filtered over the charcoal, and the filtrate was acidified by 50 percent H2SO4. The resulting solid was filtered and dried, yielding 3-Fluoro-4-methoxyphenylacetic acid. | [References]
[1] Collection of Czechoslovak Chemical Communications, 1990, vol. 55, # 1, p. 296 - 306
[2] European Journal of Medicinal Chemistry, 2014, vol. 87, p. 508 - 518
[3] Monatshefte fuer Chemie, 1955, vol. 86, p. 511,515
[4] DRP/DRBP Org.Chem.,
[5] Chemische Berichte, 1952, vol. 85, p. 577,580 |
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