| Identification | Back Directory | [Name]
IR-415) | [CAS]
452967-14-5 | [Synonyms]
IR-415)
IR415
(IR 415
IR415 >=98% (HPLC)
1-[3-(1-Imidazolyl)propyl]-3-(2,4-difluorophenyl)thiourea | [Molecular Formula]
C13H14F2N4S | [MDL Number]
MFCD00238878 | [MOL File]
452967-14-5.mol | [Molecular Weight]
296.34 |
| Chemical Properties | Back Directory | [Boiling point ]
439.6±55.0 °C(Predicted) | [density ]
1.32±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO: 125 mg/mL (421.81 mM) | [form ]
Solid | [pka]
11?+-.0.70(Predicted) | [color ]
White to off-white | [InChI]
1S/C13H14F2N4S/c14-10-2-3-12(11(15)8-10)18-13(20)17-4-1-6-19-7-5-16-9-19/h2-3,5,7-9H,1,4,6H2,(H2,17,18,20) | [InChIKey]
KRSBPLFMLHNMPU-UHFFFAOYSA-N | [SMILES]
S=C(NC1=C(F)C=C(F)C=C1)NCCCN2C=NC=C2 |
| Hazard Information | Back Directory | [Uses]
IR415 is a potent anti-HBV agent and inhibits HBV replication by blocking the HBx activity. IR415 selectively interacts with HBx (Kd=2 nM) and blocks HBV-mediated RNAi suppression, reverses the inhibitory effect of HBx protein on the activity of the dicer endoribonuclease[1]. HBx: hepatitis B virus X protein. | [Biological Activity]
HBx is a viral suppressor of host defenses consisting of RNAi-based silencing of viral genes. It is important for HBV replication and also functions as an RNAi suppressor protein. HBx is considered as emerging target for anti-viral therapy.''selective inhibitor of Hepatitis B Virus X Protein (HBx) | [References]
[1] Ghosh S, et al. An?RNAi-based?high-throughput?screening?assay?to?identify?small?molecule?inhibitors?of?hepatitis?B?virus?replication.J Biol Chem.?2017 Jul 28;292(30):12577-12588. DOI:10.1074/jbc.M117.775155 |
|
| Company Name: |
Energy Chemical
|
| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
| Company Name: |
Merck KGaA
|
| Tel: |
21-20338288 |
| Website: |
www.sigmaaldrich.cn |
| Company Name: |
MedChemExpress
|
| Tel: |
021-58955995 |
| Website: |
www.medchemexpress.com |
|