| Identification | Back Directory | [Name]
7-CHLOROIMIDAZO[1,2-A]PYRIDINE | [CAS]
4532-25-6 | [Synonyms]
7-CHLOROIMIDA
7-Chloroimidazo[1,2-a]pyr...
7-Chloroimdazo[1,2-A]pyridine
7-chloroimidazo[1,2-α]pyridine
7-Chloroimidazo[1,2-a]pyridine
7-chloroimidazo[1,2-α]pyridine
IMidazo[1,2-a]pyridine, 7-chloro-
7-CHLOROIMIDAZO[1,2-A]PYRIDINE 98% | [Molecular Formula]
C7H5ClN2 | [MDL Number]
MFCD08275126 | [MOL File]
4532-25-6.mol | [Molecular Weight]
152.58 |
| Chemical Properties | Back Directory | [Melting point ]
49-51 ºC | [density ]
1.35 | [storage temp. ]
Inert atmosphere,Room Temperature | [pka]
5.21±0.50(Predicted) | [Appearance]
Light yellow to brown Solid |
| Hazard Information | Back Directory | [Synthesis]
Synthesis of 7-chloroimidazo[1,2-a]pyridine (Compound 65-3) [0000229]: To an ethanol (15 mL) suspension of Compound 65-2 (HCl) was added sodium bicarbonate powder (3.3 g, 38.4 mmol, 4 eq.) and 50% aqueous chloroacetaldehyde (2.26 g, 14.4 mmol, 1.5 eq.). The reaction mixture was heated to reflux for 4 hours followed by stirring at room temperature for 16 hours. Upon completion of the reaction, the solvent was removed by concentration under reduced pressure. The residue was dissolved in water (10 mL) and ethyl acetate (10 mL) for liquid-liquid separation. The aqueous phase was further extracted with ethyl acetate (2 x 5 mL). All organic layers were combined, dried with anhydrous sodium sulfate, filtered and concentrated under reduced pressure to give compound 65-3 as a dark yellow oil (980 mg, 89% yield). | [References]
[1] Bioorganic and Medicinal Chemistry Letters, 2013, vol. 23, # 3, p. 750 - 756
[2] Patent: WO2013/123215, 2013, A2. Location in patent: Paragraph 0000229
[3] Patent: EP2565185, 2013, A1. Location in patent: Paragraph 0114-0115
[4] European Journal of Medicinal Chemistry, 2015, vol. 94, p. 123 - 131
[5] Patent: WO2008/78100, 2008, A2. Location in patent: Page/Page column 93-94 |
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