| Identification | More | [Name]
7-Nitroindole | [CAS]
6960-42-5 | [Synonyms]
7-NITRO-1H-INDOLE
7-NITROINDOLE
TIMTEC-BB SBB003947
7-nitro-indol
7-Nitroindole,97%
7-Nitroindole ,98% | [EINECS(EC#)]
677-504-8 | [Molecular Formula]
C8H6N2O2 | [MDL Number]
MFCD00005683 | [Molecular Weight]
162.15 | [MOL File]
6960-42-5.mol |
| Chemical Properties | Back Directory | [Appearance]
yellow crystalline powder | [Melting point ]
94-98 °C (lit.) | [Boiling point ]
288.82°C (rough estimate) | [density ]
1.3264 (rough estimate) | [refractive index ]
1.5770 (estimate) | [storage temp. ]
Sealed in dry,Room Temperature | [pka]
13.96±0.30(Predicted) | [Water Solubility ]
slightly soluble | [Detection Methods]
HPLC,NMR | [BRN ]
130874 | [CAS DataBase Reference]
6960-42-5(CAS DataBase Reference) |
| Safety Data | Back Directory | [Hazard Codes ]
Xn,Xi | [Risk Statements ]
R68:Possible risk of irreversible effects. | [Safety Statements ]
S36/37:Wear suitable protective clothing and gloves .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) . | [WGK Germany ]
3
| [RTECS ]
NM1169000
| [Hazard Note ]
Irritant | [HazardClass ]
IRRITANT-HARMFUL | [HS Code ]
29339900 |
| Hazard Information | Back Directory | [Chemical Properties]
yellow crystalline powder | [Uses]
7-Nitroindole is a reagent used in chemical synthesis. It has been used in the synthesis of protein kinase and inosine monophosphate inhibitors, beta3 agonists and CCK-1 receptor modulators. 7-Nitroindole has also been used as a photochemical precursor of the 2'-deoxyribonolactone analog. | [Application]
Reactant for preparation of:
Protein kinase inhibitors
Potential fructose 1,6-bisphosphatase inhibitors
Factor Xa inhibitors
Antagonist of the mineralocorticoid receptor
Antitumor sulfonamides
Inosine monophosphate dehydrogenase (IMPDH) inhibitors
Subtype-selective cyclooxygenase (COX) inhibitors
Thrombin protease-activated receptor (PAR-1) ligands | [Synthesis Reference(s)]
Canadian Journal of Chemistry, 42, p. 1235, 1964 DOI: 10.1139/v64-189 |
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