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455348-63-7

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455348-63-7 Structure

455348-63-7 Structure
IdentificationBack Directory
[Name]

CpG2007
[CAS]

455348-63-7
[Synonyms]

CpG2007
Chemical PropertiesBack Directory
[form ]

Solid
[color ]

White to off-white
[Sequence]

DNA, d(P-thio)(T-C-G-T-C-G-T-T-G-T-C-G-T-T-T-T-G-T-C-G-T-T)
Hazard InformationBack Directory
[Uses]

ODN 2007, a class B CpG ODN (oligodeoxynucleotide), is a Toll-like receptor (TLR) ligand. ODN 2007 can be used as an immunomodulator, vaccine adjuvant, and enhance immune responses in mammals, fish, and humans. ODN 2007 sequence: 5'-TCGTCGTTGTCGTTTTGTCGTT-3'[1][2][3].
[in vivo]

ODN 2007 (intraperitoneal injection, 1 μg, once) can enhance the immune response by regulating the expression of immune system-related genes in zebrafish infected withVibrio traumaticus FJ03-X2[2].

Animal Model:Zebrafish infected with Vibrio traumaticus FJ03-X2[2]
Dosage:1 μg
Administration:Intraperitoneal injection; once
Result:Showed a cumulative mortality rate of 15.0% in treated group while the control group reached 42.1%.
Showed a significant decrease in the expression levels of all intestinal immune-related genes such as TNF、IFNg1-2、IL-1β、IL-10, especially IL-1β decreased by 99.88%.
[References]

[1] Tamiru N Alkie, et al. Characterization of Innate Responses Induced by PLGA Encapsulated- and Soluble TLR Ligands In Vitro and In Vivo in Chickens. PLoS One. 2017 Jan 3;12(1):e0169154. DOI:10.1371/journal.pone.0169154
[2] Hua Chen, et al. CpG-ODN 2007 protects zebrafish (Danio rerio) against Vibrio vulnificus infection. Aquac Res. 2021; 52: 897-905.
[3] Audesh Bhat, et al. Role of Hsp90 in CpG ODN mediated immunostimulation in avian macrophages. Mol Immunol. 2010 Mar;47(6):1337-46. DOI:10.1016/j.molimm.2009.12.011
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