| Identification | Back Directory | [Name]
1H-Indole-3-acetyl chloride, α-oxo-2-phenyl- | [CAS]
4560-08-1 | [Synonyms]
1H-Indole-3-acetyl chloride, α-oxo-2-phenyl- | [Molecular Formula]
C16H10ClNO2 | [MOL File]
4560-08-1.mol | [Molecular Weight]
283.71 |
| Chemical Properties | Back Directory | [Melting point ]
132.5 °C | [Boiling point ]
532.2±52.0 °C(Predicted) | [density ]
1.369±0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
14.09±0.30(Predicted) | [color ]
Light yellow to green yellow |
| Hazard Information | Back Directory | [Uses]
TSPO ligand-1 is the ligand of AUTAC4 (HY-134640) that can be used in the synthesis of PROTACs. TSPO ligand-1 is a mitochondrial outer membrane transmembrane structural domain protein can bind to AUTAC4 and regulate mitochondrial autophagy to promote targeted mitochondrial renewal. TSPO ligand-1 is also involved in the transport of cholesterol from the outer to inner mitochondrial membrane and serves as a sensitive biomarker of brain injury and neurodegeneration[1][2]. | [References]
[1] Takahashi D, et, al. AUTACs: Cargo-Specific Degraders Using Selective Autophagy. Mol Cell. 2019 Dec 5;76(5):797-810.e10. DOI:10.1016/j.molcel.2019.09.009
[2] Tina Notter, et al. Neuronal activity increases translocator protein (TSPO) levels. Mol Psychiatry. 2021 Jun;26(6):2025-2037. doi: 10.1038/s41380-020-0745-1. Epub 2020 May 12. DOI:10.1038/s41380-020-0745-1
[3] Benjamin B Tournier, et al. Astrocytic TSPO Upregulation Appears Before Microglial TSPO in Alzheimer's Disease. J Alzheimers Dis. 2020;77(3):1043-1056. doi: 10.3233/JAD-200136. DOI:10.3233/JAD-200136
[4] Lan N Tu, et al. Translocator Protein (TSPO) Affects Mitochondrial Fatty Acid Oxidation in Steroidogenic Cells. Endocrinology. 2016 Mar;157(3):1110-21. doi: 10.1210/en.2015-1795. Epub 2016 Jan 7. DOI:10.1210/en.2015-1795 |
|
|