| Identification | More | [Name]
(DIFLUOROMETHOXY)BENZENE | [CAS]
458-92-4 | [Synonyms]
ALPHA,ALPHA-DIFLUOROANISOLE
(DIFLUOROMETHOXY)BENZENE
α,α-Difluoroanisole
1,1-difluoroanisole
alpha,alpha-Difluoroanisole,98+%
A,A-DIFLUOROANISOLE
alpha-Difluoroanisole
(Difluoromethyl)phenyl ether
Difluoromethyl(phenyl) ether
Difluoromethylphenyl ether
Phenyl(difluoromethyl) ether | [EINECS(EC#)]
207-283-1 | [Molecular Formula]
C7H6F2O | [MDL Number]
MFCD00068184 | [Molecular Weight]
144.12 | [MOL File]
458-92-4.mol |
| Hazard Information | Back Directory | [Chemical Properties]
Clear colorless liquid | [Synthesis]
At room temperature, 0.28 g (0.003 mol) of phenol, 1.7 g (0.03 mol) of potassium hydroxide (KOH), an appropriate amount of water, and dioxane were added as solvents to a 50 mL round bottom flask. The reaction mixture was heated to 50°C, followed by the passage of trifluoromethane gas bubbling through the reaction solution for 2 hours. After completion of the reaction, the mixture was stirred at 50 °C overnight. The yield of difluoromethoxybenzene was calculated to be 70% by 19F NMR analysis (Figures 1 and 2 show the 19F NMR decoupling and proton coupling spectra of the reaction mixture and the purified difluoromethoxybenzene, respectively), using the 19F NMR integral signal of the HF2CO group as an internal standard. | [References]
[1] Patent: WO2014/113412, 2014, A1. Location in patent: Page/Page column 4
[2] Journal of Organic Chemistry, 2013, vol. 78, # 17, p. 8904 - 8908 |
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J & K SCIENTIFIC LTD.
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18210857532 18210857532 |
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https://www.jkchemical.com |
| Company Name: |
Cool Pharm, Ltd
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021-60455363 18019463053 |
| Website: |
www.coolpharm.com |
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