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461023-63-2

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461023-63-2 Structure

461023-63-2 Structure
IdentificationBack Directory
[Name]

Hydrochloride
[CAS]

461023-63-2
[Synonyms]

GW873140A
Aplaviroc(HCl)
Aplaviroc hydrochloride
[Molecular Formula]

ClH
[MDL Number]

MFCD34187346
[MOL File]

461023-63-2.mol
[Molecular Weight]

36.4609
Chemical PropertiesBack Directory
[storage temp. ]

Store at -20°C
[solubility ]

DMSO : 500 mg/mL (814.11 mM; Need ultrasonic)
[form ]

Solid
[color ]

White to off-white
Hazard InformationBack Directory
[Uses]

Treatment of HIV infection.
[in vivo]

The concentration of Aplaviroc (AK602) reached the maximal concentration immediately after intraperitoneal administration and decreased rapidly[2].
Aplaviroc (AK602, 60 mg/kg, bid, daily) suppresses R5 HIV-1 viremia in hu-PBMC-NOG mice[2].

Animal Model:hu-PBMC-NOG mice[2].
Dosage:60 mg/kg.
Administration:Single intraperitoneal administration, bid, daily.
Result:The numbers of CD4+ cells/μL in saline-treated mice were significantly less than those of AK602-treated, ddI-treated, or uninfected mice.
[IC 50]

HIV-1Ba-L: 0.4 nM (IC50); HIV-1JRFL: 0.1 nM (IC50); HIV-1MOKW: 0.2 nM (IC50); CCR5
[storage]

Store at -20°C
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