| Identification | Back Directory | [Name]
Hydrochloride | [CAS]
461023-63-2 | [Synonyms]
GW873140A
Aplaviroc(HCl)
Aplaviroc hydrochloride | [Molecular Formula]
ClH | [MDL Number]
MFCD34187346 | [MOL File]
461023-63-2.mol | [Molecular Weight]
36.4609 |
| Hazard Information | Back Directory | [Uses]
Treatment of HIV infection. | [in vivo]
The concentration of Aplaviroc (AK602) reached the maximal concentration immediately after intraperitoneal administration and decreased rapidly[2].
Aplaviroc (AK602, 60 mg/kg, bid, daily) suppresses R5 HIV-1 viremia in hu-PBMC-NOG mice[2].
| Animal Model: | hu-PBMC-NOG mice[2]. | | Dosage: | 60 mg/kg. | | Administration: | Single intraperitoneal administration, bid, daily. | | Result: | The numbers of CD4+ cells/μL in saline-treated mice were significantly less than those of AK602-treated, ddI-treated, or uninfected mice. |
| [IC 50]
HIV-1Ba-L: 0.4 nM (IC50); HIV-1JRFL: 0.1 nM (IC50); HIV-1MOKW: 0.2 nM (IC50); CCR5 | [storage]
Store at -20°C |
|
| Company Name: |
InvivoChem
|
| Tel: |
13549236410 |
| Website: |
https://www.invivochem.cn/ |
|