| Identification | Back Directory | [Name]
5-bromo-2-chloro-4’-ethoxydiphenylmethane | [CAS]
461432-23-5 | [Synonyms]
Dapagliflozin-13
Dapaglifozin DAP Bromo
5-broMo-2-chloro-4&rsquo
Dapagliflozin Impurity 15
4-(Dibenzofuranyl)boronic
Dapagliflozin Impurity 82
Dapagliflozin Intermediate 2
Dapagliflozin Bromo impurity
Dapagliflozin Intermediate 1
Dapagliflozin Intermediate II
4-Bromo-1-chloro-2-(4-ethoxybenzyl)
4-Brom-1-chlor-2-(4-ethoxybenzyl)benzol
Dapagliflozin Despyranose Bromo Impurity
(5-bromo-2-chlorobenzyl)-4-ethoxybenzene
4-(5-Brom-2-chlorbenzyl)phenyl-ethylether
5-bromo-2-chloro-4’-ethoxydiphenylmethane
4-Bromo-1-ChIoro 2-4-EthoxybenzyI-Benzene
5-Bromo-2-chIoro-4’-ethoxydiphenyImethane
4-bromo-l-chloro-2-(4-ethoxybenzyl)benzene
1-(5-broMo-2-chlorobenzyl)-4-ethoxybenzene
4-(5-Bromo-2-chlorobenzy)phenylethyl ester
2-(4-Methoxybenzyl)-4-broMo-1-chlorobenzene
2-(4-ethoxybenzyl)-4-bromo-1-chloro benzene
4-broMo-1-chloro-2-[(4-ethoxyphenyl)Methyl]-
4-(5- bromo -2- chlorobenzyl) phenethyl ether
4-(5-Bromo-2-chlorobenzyl)phenyl ethyl ether
Supply 5-bromo-2-chloro-4'-ethoxydiphenylmethane
4-bromo-1-chloro-2-[(4-ethoxyphenyl)methyl]benzene
Benzene, 4-bromo-1-chloro-2-[(4-ethoxyphenyl)methyl]-
5-bromo-2-chloro-4'-ethoxydiphenylmethane###461432-23-5
4-(3-((1-ethoxyethoxy)methyl)-4-bromophenoxy)benzonitrile
5-bromo-2-chloro-4’-ethoxydiphenylmethane ISO 9001：2015 REACH
Dapagliflozin Intermediate/ 5-Bromo-2-Chloro-4'-Ethoxydiphenylmethane
5-bromo-2-chloro-4’-ethoxydiphenylmethane, Or 4-(5-Bromo-2-chlorobenzyl)phenyl ethyl ether
5-bromo-2-chloro-4-ethoxydiphenylmethaneQ: What is
5-bromo-2-chloro-4-ethoxydiphenylmethane Q: What is the CAS Number of
5-bromo-2-chloro-4-ethoxydiphenylmethane Q: What is the storage condition of
5-bromo-2-chloro-4-ethoxydiphenylmethane Q: What are the applications of
5-bromo-2-chloro-4-ethoxydiphenylmethane | [EINECS(EC#)]
636-921-5 | [Molecular Formula]
C15H14BrClO | [MDL Number]
MFCD11042292 | [MOL File]
461432-23-5.mol | [Molecular Weight]
325.64 |
| Chemical Properties | Back Directory | [Boiling point ]
393.0±32.0 °C(Predicted) | [density ]
1.371±0.06 g/cm3(Predicted) | [storage temp. ]
Sealed in dry,Room Temperature | [solubility ]
Acetonitrile (Slightly), DMSO (Slightly), Methanol (Slightly) | [form ]
Low-Melting Solid | [color ]
White to Off-White | [Stability:]
Stable under recommended storage conditions., Stable Under Recommended Storage C | [InChI]
InChI=1S/C15H14BrClO/c1-2-18-14-6-3-11(4-7-14)9-12-10-13(16)5-8-15(12)17/h3-8,10H,2,9H2,1H3 | [InChIKey]
ZUNCHZBITMUSRD-UHFFFAOYSA-N | [SMILES]
C1(Cl)=CC=C(Br)C=C1CC1=CC=C(OCC)C=C1 |
| Hazard Information | Back Directory | [Uses]
5-Bromo-2-chloro-4'-ethoxydiphenylmethane(461432-23-5) is a hydrocarbon derivative and can be used as an intermediate for dapagliflozin.
| [Synthesis]
Oxalyl chloride (0.8 mL) was added to a solution of 5-bromo-2-chlorobenzoic acid (2 g) in dichloromethane (20 mL) and dimethylformamide (0.2 mL) under a nitrogen atmosphere. The reaction mixture was stirred for one hour at 25° C to 30° C. After completion of the reaction, the reaction mixture was concentrated under a vacuum at 40° C to 45° C. to obtain an oily residue. The oily residue was dissolved in dichloromethane (20 mL) and cooled to 0° C. To this solution, phenol (1.1 mL) and aluminium chloride (2.3 g) were added at 0° C. to 5° C. The reaction mixture was stirred at 0° C to 5° C for 2 hours. The reaction mixture was allowed to warm to about 20° C, and triethylsilane (3.4 mL) was slowly added to it at the same temperature. The reaction mixture was stirred for about 36 hours from 20° C to 25° C. After completion of the reaction, 4-bromo-1-chloro-2-(4-ethoxybenzyl)benzene was obtained by further purification.
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| Company Name: |
Energy Chemical
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| Telephone: |
400-0056266 |
| Website: |
www.energy-chemical.com |
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