| Identification | More | [Name]
1-Phenyl-2-pyrrolidinone | [CAS]
4641-57-0 | [Synonyms]
1-PHENYL-2-PYRROLIDINONE
1-PHENYL-2-PYRROLIDONE
1-PHENYLPYRROLIDIN-2-ONE
N-PHENYL-2-PYRROLIDINONE
N-PHENYL PYRROLIDONE
VITAS-BB TBB000660
2-Pyrrolidinone,1-phenyl-
N-Phenyl-2-pyrrolidone
N-Phenylbutyrolactam
N-Phenylbutyrolactam~N-Phenyl-2-pyrrolidone
Phenylpyrrolidone
N-phenylpyrrolidinone
Phenylpyrrolidone>99%
N-Phenylbutyrolactame
N-Phenyl-2-pyrrolidinon
1-PHENYL-2-PYRROLIDONE 99+% | [EINECS(EC#)]
225-069-6 | [Molecular Formula]
C10H11NO | [MDL Number]
MFCD00003192 | [Molecular Weight]
161.2 | [MOL File]
4641-57-0.mol |
| Questions And Answer | Back Directory | [Synthesis]
In a 10 mL Shrek tube, N-phenylcyclohexylamine (0.5 mmol, 81 mg), acetonitrile (5 mL), anhydrous copper acetate (1 mmol, 181 mg), potassium iodide (1 mmol, 166 mg), and potassium persulfate complex salt (Oxone, 615 mg, 1 mmol) were added sequentially. After evacuation and oxygen purging (1 atm), the tube was placed in an 80 °C oil bath and stirred for 12 h. Then, 10 mL of saturated brine was added to quench the reaction, and the mixture was extracted with ethyl acetate (10 mL × 3). The organic phases were combined and dried over anhydrous sodium sulfate. Filter, evaporate to dryness, and separate by silica gel column chromatography (petroleum ether/ethyl acetate = 3/1) to give a white solid product, 1-Phenyl-2-pyrrolidinone (47 mg, 58%). |
| Chemical Properties | Back Directory | [Melting point ]
67-69 °C (lit.) | [Boiling point ]
123 °C/0.2 mmHg (lit.) | [density ]
1.0840 (rough estimate) | [refractive index ]
1.5200 (estimate) | [Fp ]
123°C/0.2mm | [storage temp. ]
Sealed in dry,Room Temperature | [solubility ]
Chloroform (Slightly), Ethyl Acetate, Methanol (Slightly) | [form ]
Solid | [pka]
0.54±0.20(Predicted) | [color ]
Light Beige | [Water Solubility ]
Soluble in chloroform and ethyl Acetate. Insoluble in water. | [BRN ]
130685 | [InChI]
1S/C10H11NO/c12-10-7-4-8-11(10)9-5-2-1-3-6-9/h1-3,5-6H,4,7-8H2 | [InChIKey]
JMVIVASFFKKFQK-UHFFFAOYSA-N | [SMILES]
O=C1CCCN1c2ccccc2 | [CAS DataBase Reference]
4641-57-0(CAS DataBase Reference) | [NIST Chemistry Reference]
2-Pyrrolidinone, 1-phenyl-(4641-57-0) |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S37/39:Wear suitable gloves and eye/face protection . | [WGK Germany ]
3
| [HazardClass ]
IRRITANT | [HS Code ]
29337900 | [Storage Class]
11 - Combustible Solids | [Hazard Classifications]
Eye Irrit. 2
Skin Irrit. 2
STOT SE 3 |
| Hazard Information | Back Directory | [Chemical Properties]
Light Beige Solid | [Uses]
A novel derivative of 1-phenyl-2-pyrrolidinone, blebbistatin, inhibits non-muscle myocin II activity with high specificity. | [Synthesis Reference(s)]
Journal of the American Chemical Society, 77, p. 4079, 1955 DOI: 10.1021/ja01620a034
Synthesis, p. 856, 1985 | [General Description]
A novel derivative of 1-phenyl-2-pyrrolidinone, blebbistatin, inhibits non-muscle myocin II activity with high specificity. |
|
| Company Name: |
J & K SCIENTIFIC LTD.
|
| Telephone: |
18210857532 18210857532 |
| Website: |
https://www.jkchemical.com |
| Company Name: |
Alfa Aesar
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| Telephone: |
400-6106006 |
| Website: |
http://chemicals.thermofisher.cn |
| Company Name: |
Energy Chemical
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| Telephone: |
400-0056266 |
| Website: |
www.energy-chemical.com |
| Company Name: |
Maya High Purity Chemicals
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| Telephone: |
+86 (573) 82222445 (0)18006601000 452520369 |
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www.chemicalbook.com/ShowSupplierProductsList15221/0_EN.htm |
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