| Identification | Back Directory | [Name]
Bullatine B | [CAS]
466-26-2 | [Synonyms]
Xuan-wu 3
Bullatine B
Neoline,Bullatine B
Dideacetyldelphisine
Aconitane-1,8,14-triol, 20-ethyl-6,16-dimethoxy-4-(methoxymethyl)-, (1-alpha,6-alpha,14-alpha,16-beta)- | [Molecular Formula]
C24H39NO6 | [MDL Number]
MFCD01673484 | [MOL File]
466-26-2.mol | [Molecular Weight]
437.573 |
| Chemical Properties | Back Directory | [Melting point ]
153-154 °C | [Boiling point ]
578.3±50.0 °C(Predicted) | [density ]
1.31±0.1 g/cm3(Predicted) | [storage temp. ]
2-8°C | [solubility ]
Chloroform (Sparingly), Methanol (Very Slightly) | [form ]
Solid | [pka]
13.32±0.70(Predicted) | [color ]
White to Off-White |
| Hazard Information | Back Directory | [Chemical Properties]
It is a white crystalline powder, soluble in organic solvents such as methanol, ethanol, and DMSO. It comes from the tuberous roots of Aconitum carmichaelii and the roots of Artemisia sclerotium produced in various parts of Yunnan. It contains artemisinin A and artemisinin B, and artemisinin B has been proven to be neolin. | [Uses]
Bullatine B is an aconitine-type alkaloid which exhibits antiarrhythmic properties. | [in vivo]
Neoline (10 mg/kg/day; sc; 10 days) alleviates oxaliplatin-induced peripheral neuropathy. Neoline inhibits paclitaxel- or partial sciatic nerve injury-induced allodynia in mice model[1].
Neoline (1-10 mg/kg; sc; single dose) shows antinociceptive effect and significantly increases the mechanical nociceptive threshold in diabetic mices[2].
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